Registration Dossier
Registration Dossier
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EC number: 212-740-3 | CAS number: 865-47-4
Endpoint summary
Administrative data
Description of key information
Key study for skin irritation according to OECD guideline 404: corrosive
Key value for chemical safety assessment
Additional information
A corrosive result was reported after 1 min treatment with potassium tert-butanolate under semi-occlusive conditions (Evonik, 1989). Study was performed according to OECD guideline 404 . Here, one rabbit was treated with the test substance (shaved skin) and strong necrosis was detected after 1 hour. After 48 hours, strong necrosis and hardening of the skin were observed.
As the product corrodes the skin, it can be expected to have a similar effect on the eyes.
Justification for classification or non-classification
Based on the available data, classification is proposed: C: R35 (EU); GHS: Skin Corr. 1A (H314).
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