Androst-4-ene-3,17-dione

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08 to 16 Aug 2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

ring method

Key result

Surface tension:

68.5 mN/m

Temp.:

20 °C

Conc.:

90 vol%

Remarks on result:

other: mean value of 5 measurements

Validity criteria for the measurement of the surface tension:

Target condition according to guideline OECD 105:	Actual condition according to the study:	Validity criteria met:
A solution of the substance is prepared in distilled water. The concentration of this solution should be 90 % of the saturation solubility of the substance in water; when this concentration exceeds 1 g/ L, a concentration of 1 g/ L is used for testing.	An aliquot of 232 mg of the test substance was stirred with 230 ml double distilled water at 20.0  0.5°C for 21 hours. After the stirring period, a sample of the solution was centrifuged at 3500 g and 20°C for 5 minutes. Thereafter, 90 ml of the aqueous phase was mixed with 10 ml double distilled water to obtain the test solution at 90% of the test substance saturation solubility in water.	Yes
The measurement shall be made at approximately 20°C and shall be controlled to within ± 0.5 °C.	The temperature was kept at 20 +/- 0.5 °C	Yes
The measurement results: individual readings, their arithmetic mean and the corrected mean; concentration of the solution should be stated.	All measurement results are reported.	Yes

 

Conclusions:

The surface tension was determined as 68.5 mN/m by ninety percent saturation concentration of Androst-4-ene-3,17-dione in water at 20 °C.

Executive summary:

The OECD harmonized ring method was applied for the determination of the surface tension of Androst-4-ene-3,17-dione. The surface tension of a test solution at 90% of the test substance saturation solubility in water and at 20°C was 68.5 mN/m.

A test substance with a surface tension < 60 mN/m will be regarded as being a surface active material. Therefore Androst-4-ene-3,17-dione is considered not to be surface active.

Description of key information

The surface tension was determined as 68.5 mN/m by ninety percent saturation concentration of Androst-4-ene-3,17-dione in water at 20 °C.

Key value for chemical safety assessment

Surface tension:

68.5

Additional information

A test substance with a surface tension < 60 mN/m will be regarded as being a surface active material. Therefore Androst-4-ene-3,17-dione is considered not to be surface active.