Potassium iodate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer reviewed journal.

Data source

Reference

Reference Type:

publication

Title:

Case report of test chemical

Author:

Singalavanija et al.,

Year:

2000

Bibliographic source:

Retina,; 2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

The clinical manifestations, toxic dosage of iodate, and ocular changes in five patients who had taken a test chemical overdose were analyzed. Electroretinography, visual evoked potential (VEP), and fundus fluorescein angiography (FA) were performed to study retinal function and changes.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Potassium iodate

EC Number:

231-831-9

EC Name:

Potassium iodate

Cas Number:

7758-05-6

Molecular formula:

HIO3.K

IUPAC Name:

potassium iodate

Details on test material:

- Name of test material (as cited in study report): Potassium iodate
- Substance type: Inorganic
- Physical state: Solid

Test animals / tissue source

Species:

human

Details on test animals or tissues and environmental conditions:

TEST ANIMALS
- Age at study initiation:22-65 yrs.

Test system

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

KIO3 solution at a concentration between 187 and 470 mg/kg body weight was ingested.

Duration of treatment / exposure:

2 - 12 hours

Observation period (in vivo):

3 months

Number of animals or in vitro replicates:

Two men and three women

Results and discussion

In vivo

Results

Irritation parameter:

other: Retinal pigment epithelial (RPE) window defects

Basis:

mean

Time point:

other: 2-12 hours

Score:

20

Max. score:

80

Reversibility:

not specified

Remarks on result:

other: Two men and three women (age 22-65 years) ingested KIO3 solution at a concentration between 187 and 470 mg/kg body weight. Visual acuity ranged from light perception with projection to counting fingers and decreased from 2 to 12 hours after ingestion.

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

The test chemical can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells. On the basis of observed effects, the test chemical can be considered as irritating to the human eyes.

Executive summary:

The clinical manifestations, toxic dosage of iodate, and ocular changes in five patients who had taken a overdose of test chemical were analyzed. Electroretinography, visual evoked potential (VEP), and fundus fluorescein angiography (FA) were performed to study retinal function and changes.

Two men and three women (age 22-65 years) ingested test chemical solution at a concentration between 187 and 470 mg/kg body weight. Visual acuity ranged from light perception with projection to counting fingers and decreased from 2 to 12 hours after ingestion. Fundus FA showed bilateral extensive areas of retinal pigment epithelial (RPE) window defects, and electroretinography and VEP showed marked impairment of retinal function. Visual acuity improved from counting fingers to 20/80 in 3 months.

The test chemical can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells.

On the basis of observed effects, the test chemical can be considered as irritating to the human eyes.