Methanesulphonyl chloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

A 10% dilution in PEG 400 of Methanesulfonyl chloride was administered by gavage to 5 groups of  5 male rats. Surviving animals were observed for at least 7 days.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methanesulphonyl chloride

EC Number:

204-706-1

EC Name:

Methanesulphonyl chloride

Cas Number:

124-63-0

Molecular formula:

CH3ClO2S

IUPAC Name:

methanesulfonyl chloride

Details on test material:

Test article name : Methane sulfonyl chloride
Cas n°: 124-63-0
Origin: Pennwalt Corporation
Batch: no data
Purity: no data

Test animals

Species:

rat

Strain:

other: WBS/W

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Species: Rat Strain: WBS/W
- Source: no data
- Age: no data
- Weight at dosing: 240 g
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Housing: no data
- Diet: no data Water: no data
- Temperature: no data
- Humidity: no data
- Air changes: no data
- Photoperiod: no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

polyethylene glycol

Details on oral exposure:

A 10% dilution in PEG 400 was administered by stomach tube to 5 groups of  5 male rats. Surviving animals were observed for at least 7 days. No additional informations are available.

Doses:

100, 141, 200, 283 and 400 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Statistics:

no data

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

255 mg/kg bw

95% CL:

205 - 317

Mortality:

Oral dose         no. rats        % Mortality
(mg/kg)         dead/total
100                0/5                0
141                0/5                0
200                1/5                20
283                3/5                60
400                5/5                100

Clinical signs:

other: Symptomatology : General distress (immediate) and hypotonia. Surviving animals showed significant losses in body weight for one to 5 days but were recovered 2 to 7 days after  treatment.

Gross pathology:

Autopsies revealed the glandular gastric mucosa to be severely hemorrhagic.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008

Conclusions:

Based on single exposure animal tests, methanesulfonyl chloride is considered to be toxic if swallowed (oral LD50 = 255 mg/kg in rats).

Executive summary:

In an acute oral toxicity study, methansulfonyl chloride (purity unknown) was administered to 5 groups of 5 male WBS/W rats at dose levels of 100, 141, 200, 283 and 400 mg/kg.

Mortality was 0, 0, 20, 60 and 100% at the dose level of 100, 141, 200, 283 and 400 mg/kg, respectively. Clinical signs recorded prior to death were general distress (immediate) and hypotonia. Surviving animals showed significant losses in body weight for one to 5 days but were recovered 2 to 7 days after treatment. The oral LD5O was 255 mg/kg in male rats with a 95% confidence interval limits of 205-317 mg/kg.