N,N'-bis(3-aminopropyl)ethylenediamine

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientifically acceptable publication

Data source

Reference

Reference Type:

publication

Title:

Synthesis of Aminoethyl Derivatives of αω-Alkylenediamines and Structure-Activity Relationships for the Polyamine-Bovine Plasma Amine Oxidase System.

Author:

Israel M and Modest EJ

Year:

1971

Bibliographic source:

J Med Chemistry 14: 1042-1047

Materials and methods

Type of study / information:

Antitumour activity

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Growth-inhibitory activity in mammalian cell and bacterial systems, as well as phagocidal action on T-uneven phages, of the naturally occurring polyamines, spermine and spermidine, is known to be the result of conversion of the polyamine to a cytotoxic derivative by means of the enzyme bovine plasma amine oxidase (BPAO). In an attempt to define the geometry of the substrate molecule required for this conversion, a number of polyamine structural variants were examined for growth-inhibitory activity against KB cells (human epidermoid carcinoma) in culture in media supplemented with calf serum (contains BPAO).

Test material

Test material information

Constituent 1

Reference substance name:

N,N'-bis(3-aminopropyl)ethylenediamine

EC Number:

234-147-9

EC Name:

N,N'-bis(3-aminopropyl)ethylenediamine

Cas Number:

10563-26-5

Molecular formula:

C8H22N4

IUPAC Name:

(3-aminopropyl)({2-[(3-aminopropyl)amino]ethyl})amine