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EC number: 416-600-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-11-14 to 2005-12-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 31 July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.05 mg/L
- Temp.:
- 20 °C
- pH:
- 6
- Details on results:
- At the plateau, the concentration of [14C] HAT-Paste in water had reached:
0.0497 ± 0.0022 mg/L at 20 ± 0.5 °C
= 0.0497 * 10-6 kg/L (SI units)
(mean value of all ten fractions ± standard deviation) - Conclusions:
- The water solubility of [14-C]HAT Paste was determined by measuring the plateau concentration of the test article.
At the plateau, the concentration of [14C] HAT-Paste in water had reached:
0.0497 ± 0.0022 mg/L at 20 ± 0.5 °C
= 0.0497 * 10-6 kg/L (SI units)
(mean value of all ten fractions ± standard deviation) - Executive summary:
Findings:
Quartz sand was filled into a glass column and coated with test item.
A flow rate of 24.76 mL/h was set. After discarding the first five column volumes, fractions were collected and measured.
On the first day, no plateau was reached (downward tendency). After five consecutive fractions on the second day, the plateau was considered as reached, because variation was less than 30 % and no tendency was observed.
A second experiment with a flow rate of 12.4 mL/h was performed likewise. In this experiment, the first five fractions showed no variations greater than 30 % and no tendency.
No differences greater than 30 % in the concentrations of the solutions could be determined between the sample dates of the different flow rates, supporting the independency of solubility and flow rate.
At the plateau, the concentration of [14C] HAT-Paste in water had reached:
0.0497 ± 0.0022 mg/L at 20 ± 0.5 °C
= 0.0497 * 10-6 kg/L (SI units)(mean value of all ten fractions ± standard deviation)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1993-07-09 to 1994-10-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- EEC 92/69
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- Analytical purity: >= 99.65 %
Lot/batch No.: 93.166 - Key result
- Water solubility:
- < 0.24 mg/L
- Temp.:
- 20 °C
- pH:
- 6
- Details on results:
- The water solubility of the test article was determined to be less than the detection limit of the analytical method, i.e. < 0.24 mg/L.
- Conclusions:
- The water solubility of the test article was determined to be less than the detection limit of the analytical method, i.e. 0.24 mg/L.
- Executive summary:
The solubility in water of a substance is the saturation mass concentration of the test article in water at a given temperature.
Preliminary tests showed that the test article was insoluble in water. The water solubility could not be measured by the shake flask method, and for the column elution method, no volatile solvent was found for the test article. Therefore, this method was adapted and the test article eluted from a preparation using dimethyl formamide. The samples were analysed by HPLC. No test article was detected in the eluted samples and therefore an estimate of the detection limit of the analytical method was made by comparing the analytical signal of the lowest calibration standard with the instrument noise. The detection limit was set at twice the noise level and was determined to be less than 0.24 mg/L.
Referenceopen allclose all
Quartz sand was filled into a glass column and coated with test item.
A flow rate of 24.76 mL/h was set. After discarding the first five column volumes, fractions were collected and measured.
On the first day, no plateau was
reached (downward tendency). After five consecutive fractions on the
second day, the plateau was considered as reached, because variation was
less than 30% and no tendency was observed.
A second experiment with a flow rate of 12.4 mL/h was performed
likewise. In this experiment, the first five fractions showed no
variations greater than 30 % and no tendency.
No differences greater than 30 % in the concentrations of the solutions could be determined between the sample dates of the different flow rates, supporting the independency of solubility and flow rate.
At the plateau, the concentration of [14C] HAT-Paste in water had reached:
0.0497 ± 0.0022 mg/L
at 20 ± 0.5 °C
= 0.0497 * 10-6 kg/L (SI units)
(mean value of all ten fractions ± standard deviation)
Values
at Plateau
Flow rate [mL/h] |
Sample No. |
Concentration[µg/L] |
Mean[µg/L] |
Standard Deviation[µg/L] |
Relative Standard Deviation[%] |
24.76 |
6 |
51.1 |
49.0 |
2.3 |
4.7 |
7 |
49.0 |
||||
8 |
51.0 |
||||
9 |
45.4 |
||||
10 |
48.8 |
||||
12.4 |
1 |
45.3 |
49.0 |
2.3 |
4.7 |
2 |
50.9 |
||||
3 |
48.8 |
||||
4 |
50.8 |
||||
5 |
48.9 |
No test article was detected in the eluted samples and therefore an estimate of the detection limit of the analytical method was made by comparing the analytical signal of the lowest calibration standard with the instrument noise.
The detection limit was set at twice the noise level and was determined to be less than 0.24 mg/L.
Description of key information
The water solubility of [14-C] HAT Paste was determined according to EU Method A 6, Water solubility, using the column elution method by measuring the plateau concentration of the test article. At the plateau, the concentration of [14C] HAT-Paste in water had reached:
0.0497 ± 0.0022 mg/L at 20 ± 0.5 °C = 0.0497 * 10E-06 kg/L (SI units) (mean value of all ten fractions ± standard deviation)
According to this result, HAT Paste can be regarded as insoluble in water (< 0.1 mg/L).
A supporting study evaluated the water solubility of HAT ISO by HPLC according to EU Guideline A.6, Water solubility and OECD guideline no. 105. The water solubility of HAT ISO was determined to be below the analytical detection limit, i.e. < 0.24 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.05 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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