But-2-yne-1,4-diol

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

Type of genotoxicity: gene mutation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Similar to Guideline Study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Principles of method if other than guideline:

Method:according to OECD-Guideline 471

GLP compliance:

no

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

But-2-yne-1,4-diol

EC Number:

203-788-6

EC Name:

But-2-yne-1,4-diol

Cas Number:

110-65-6

Molecular formula:

C4H6O2

IUPAC Name:

but-2-yne-1,4-diol

Details on test material:

- Name of test material (as cited in study report): Butin2-diol.1,4
- Analytical purity: > 99%

Method

Species / strain

Species / strain / cell type:

other: Salmonella typhimurium (TA 98, TA 100, TA 1535, TA 1537, TA 1538)

Metabolic activation:

with and without

Metabolic activation system:

S-9 mix(rat liver)

Test concentrations with justification for top dose:

20 - 5000 ug/plate

Results and discussion

Test results

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

no cytotoxicity

Remarks on result:

other: other: Salmonella typhimurium (TA 98, TA 100, TA 1535, TA 1537, TA 1538)

Remarks:

Migrated from field 'Test system'.

Any other information on results incl. tables

Toxicity:

No bacteriotoxic effect was observed.

Mutagenicity:

An increase in the number of his+ revertants was not observed either without S-9 mix or after the addition of a metabolizing system.

According to the result ot the present study, the test substance Butin-2-diol-1,4 is not mutagenic in the Ames test under the experimental condition chosen here.