Methyl vinyl ether

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to Guideline study with acceptable restrictions (report not available for the submitter, no further details available; occlusive dressing [worst case]). Presumably rapid evaporation; discussion of reliability see also overall remarks.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

no

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Methyl vinyl ether

EC Number:

203-475-4

EC Name:

Methyl vinyl ether

Cas Number:

107-25-5

Molecular formula:

C3H6O

IUPAC Name:

methoxyethene

Details on test material:

methyl vinyl ether (MVE)
no further data

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

Animals were kept in rooms designed to maintain adequate environmental conditions, and were given a commercial diet and municipal water ad libitum.

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin

Amount / concentration applied:

undiluted, 0.5 mL

Duration of treatment / exposure:

4 h

Observation period:

Observations for skin reactions were made at one hour, and after 1, 2, 3, 7, 10, and 14 days per the Draize scoring method.

Number of animals:

Six male and female New Zealand White Rabbits were used for the study.

Details on study design:

Rabbits were subjected to 4 hours of contact with 0.5 ml of the undiluted, cold test material (not specified further), retained under occlusive dressings on clipped, intact skin of the animals' trunk. The animal was returned to the home cage for the 4 hour contact period. Excess test material was removed after the contact period to diminish ingestion.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: one hour, and after 1, 2, 3, 7, 10, and 14 days after exposure

Score:

0

Max. score:

4

Reversibility:

other: no irritation

Remarks on result:

other: occlusive exposure to cold liquid

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: one hour, and after 1, 2, 3, 7, 10, and 14 days after exposure

Score:

0

Max. score:

4

Reversibility:

other: no irritation

Remarks on result:

other: occlusive exposure to cold liquid

Irritant / corrosive response data:

There was no erythema, edema, or other irritation on any of 6 rabbits from 0.5 ml of undiluted sample.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information

Conclusions:

There was no erythema, edema, or other irritation in any of 6 New Zealand White rabbits one hour, and 1, 2, 3, 7, 10, or 14 days after exposure (occlusive for 4 h) to 0.5 mL of undiluted, cold liquid test substance.