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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not applicable
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(pyridin-3-yl)methanol hydrofluoride
EC Number:
700-352-1
Cas Number:
62756-44-9
Molecular formula:
C6H8FNO
IUPAC Name:
(pyridin-3-yl)methanol hydrofluoride

Test animals

Species:
rat
Strain:
other: OFA
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1701, 2551, 3401, 4252 mg/kg nicofluoromethanol

No. of animals per sex per dose:
10
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 2 667 mg/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 979 mg/kg bw
Mortality:
Mortality observed in male at 2551mg/kg (1/10), 3401mg/kg (8/10) and 4252mg/kg (10/10)
Mortality observed in female at 2551mg/kg (3/10), 3401mg/kg (10/10) and 4252mg/kg (10/10)

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information not toxic Criteria used for interpretation of results: EU