Registration Dossier
Registration Dossier
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EC number: 263-753-6 | CAS number: 62899-75-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU / OECd guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexylethylcarbamoyl chloride
- EC Number:
- 263-753-6
- EC Name:
- Cyclohexylethylcarbamoyl chloride
- Cas Number:
- 62899-75-6
- Molecular formula:
- C9H16ClNO
- IUPAC Name:
- N-cyclohexyl-N-ethylcarbamoyl chloride
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 5 ml/kg body weight
- No. of animals per sex per dose:
- 3 male 200mg/kg bw
3 female 200mg/kg bw
3 female 2000 mg/kg bw - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 300 - <= 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 3 animals / 2000 mg/kg bw Mortality: 100%
- Clinical signs:
- other: 200 mg/kg body weight were tolerated without clinical signs by male and female rats. At a dose of 2000 mg/kg body weight, the following clinical signs were observed in female rats: decreased reactivity and motility, palmospasm and labored breathing. The s
- Gross pathology:
- No gross pathologic changes were observed in animals sacrificed at the end of the study period. In animals that died during the observation period the following changes were detected:
lungs dark-red discoloration
liver dark-red discoloration
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 for rats was 300 - 500 mg/kg body weight following acute administration.
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