Registration Dossier
Registration Dossier
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EC number: 293-026-9 | CAS number: 91050-80-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (14 d) ≥ 20 mg/L BOD for natural seawater bacteria (similar to ISO 10708)
Key value for chemical safety assessment
Additional information
The toxicity of Fatty acids, C16-18, tetraesters with 3,3'-oxybis[1,2-propanediol] (CAS 91050-80-5) to microorganisms was investigated in a biodegradation study similar to ISO 10708 under GLP conditions (Hudson, 2007). The study was performed with natural seawater as inoculum. A toxicity control included in the biodegradation study with a test item concentration of 20 mg/L BOD reached biodegradation > 35% within 14 days (76% after 14 d). Thus, the test substance is not inhibitory to aquatic microorganisms. According to ECHA Guidance R.7b (ECHA, 2012) the test item concentration can be used as NOEC value for the toxicity to aquatic microorganisms. Thus, a NOEC (14 d) of ≥ 20 mg/L BOD resulted.
In addition, as Fatty acids, C16-18, tetraesters with 3,3'-oxybis[1,2-propanediol] is readily biodegradable and the applied test concentration are in the range of concentrations that can be expected in the influent of a sewage treatment plant (> water solubility, which is < 0.05 mg/L), this study is not required according to Regulation (EC) No. 1907/2006, Annex VIII, 9.1.4., Column 2.
A detailed reference list is provided in the technical dossier (see IUCLID, section 13) and within CSR.
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