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EC number: 218-059-8 | CAS number: 2044-64-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis:
The potential of the test substance to undergo hydrolytic degradation in an aquatic environment was studied in GLP conformance according to the procedures outlined in EEC's Annex V, Part C.7.2 and OECD Guideline No. 111. A Preliminary Test was performed at 50.0 ± 0.5 °C at three pH values: 4, 7, and 9. The test solutions were analyzed for the test substance using high performance liquid chromatography with ultraviolet light detection (HPLC/UV). The change in test substance concentration, over time, was calculated and reported as the percent hydrolysis. Less than 10 percent hydrolysis was observed in the pH 4, 7, and 9 test systems after 120 hours, therefore no further testing (Test 1, Test 2, or Test 3) was required. The test substance is hydrolytically stable (half-life greater than one year) at 25°C.
Biodegradation:
BOD (Biochemical Oxygen Demand) and COD (Chemical Oxygen Demand) determinations were carried out for the test substance using the EU Method C.6 (Degradation, Chemical Oxygen Demand) cited as Directive 84/449/EEC, C.9 and EU Method C.5 (Degradation: Biochemical Oxygen Demand) cited as Directive 84/449/EEC, C.8. The study was carried out in accordance with the OECD principles of Good Laboratory Practice.
The 5-day BOD value was found to be an average of 0.0069 grams of oxygen per gram of the test substance at percent concentrations of 0.020, 0.030, and 0.060. The 20-day BOD value was found to be an average of 0.011 grams of oxygen per gram of the test substance at percent concentrations of 0.020 and 0.030. The COD result is the mean of three measurements and was found to be 0.791 grams of COD per gram of the test substance. The test material is not readily biodegradable based on a BOD5/COD ratio less than 0.5. The BOD5/COD ratio was found to be 0.0087.
Adsorption/Desorption:
The study was performed in November 2012 according to OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)) and GLP.
Retention times measured for LZ705 (2.75 min (Method 1) and 2.76 min (Method 2)) are lower than the retention time of the first eluting standard Acetanilide (3.22 min (Method 1) and 3.24 min (Method 2)). This result shows that log Koc of LZ705 is lower than the calibrated range. As the Acetanilide is the reference item with lowest Koc value, no further test was performed. Using the HPLC method the log Koc of LZ705 was determined to be< 1.25.
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