Registration Dossier
Registration Dossier
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EC number: 203-973-1 | CAS number: 112-45-8
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediments:
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for test chemical is10.22L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical s nonbioaccumulative in food chain.
Additional information
Bioaccumulation: aquatic/sediments:
Predicted data study for target chemical and experimental studies for its structurally similar read across chemical have been conducted for bioaccumulation in aquatic organisms endpoint and their results are summarized below.
In first study prediction was done by using BCFBAF Program (v3.00) model of EPI suite (2018) in this study the bio concentration factor (BCF) for test chemical estimated to be 10.22L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical s non-bioaccumulative in food chain.
Next study was experimental study reviewed from authoritative database (HSDB) in this study the bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 5.70 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 488 dimensionless.
Another study was also experimental study reviewed from authoritative database (HSDB) in this study the bioaccumulation factor (BCF) value was calculated using a log Kow of 4.57 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 660 dimensionless.
Last study was also experimental study reviewed from authoritative database (HSDB) in this study the bioaccumulation factor (BCF) value was calculated using a log Kow of 5.82 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 600 dimensionless.
By considering results of all above mentioned studies it is concluded that BCF value of test chemical can be in range of 10.22 to 660 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.
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