Registration Dossier
Registration Dossier
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EC number: 482-120-7 | CAS number: -
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- [C(97)186/Final]
Test material
- Details on test material:
- - Name of test material (as cited in study report): C-4000
- Physical state: liquid
- Analytical purity: 90.06 +/- 0.44%
- Purity test date: 2008-10
- Lot/batch No.: 51V034K7
- Expiration date of the lot/batch: 2009-01-01
- Storage condition of test material: refrigerated
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Medium:
- other: corn oil
- Solubility:
- > 250 other: g/kg
- Temp.:
- 36.2 °C
- Medium:
- other: corn oil
- Solubility:
- > 5 630 other: g/kg
- Test substance stable:
- not determined
- Details on results:
- - Temperature effects:
As determined by visual observation, up to 5 mL of test substance was completely soluble in 1 mL of corn oil. The density of C-4000 is 1.0132 g/mL (2), and the density of corn oil is 0.900 g/mL. By multiplying the volumes of test substance and corn oil added by their respective densities, the weight ratio of test substance to corn oil was determined to be 5.066 g:0.900 g. This gives an approximate solubility of greater than 5,630 g/kg under
ambient conditions.
Applicant's summary and conclusion
- Conclusions:
- At 36.2°C, the solubility of C-4000 in fat was determined to be >250 g/kg.
Under ambient conditions, the solubility of C-4000 in fat was determined to be >5,630 g/kg.
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