Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Two male and two female rats per dose level were used for this study. A standard range of dose-levels was selected: 25, 200 and 2000 mg/kg. The animals were observed for signs of systemic toxicity once between 30 and 90 minutes after dosing and again between 4 and 6 hours after dosing. Subsequent observations were made once daily up to Day 8, on Day 12 and on Day 15.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
phenyl N-[2-(phenylsulfanyl)phenyl]carbamate
EC Number:
601-145-8
Cas Number:
111974-73-3
Molecular formula:
C19H15NO2S
IUPAC Name:
phenyl N-[2-(phenylsulfanyl)phenyl]carbamate
Test material form:
solid: crystalline

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
A standard volume of 10 ml/kg was dosed to each animal and the dose-level was altered by varying the concentration of the dosed preparation.
Doses:
25, 200 and 2000 mg/kg
No. of animals per sex per dose:
2
Control animals:
no
Details on study design:
Two male and two female rats per dose level were used for this study. Each animal was weighed and then fasted for 16-20 hours prior to dosing. A standard range of dose-levels was selected: 25, 200 and 2000 mg/kg.
The animals were observed for signs of systemic toxicity once between 30 and 90 minutes after dosing and again between 4 and 6 hours after dosing. Subsequent observations were made once daily up to Day 8, on Day 12 and on Day 15.
The acute oral median lethal dose was estimated from the mortality data.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: mortality
Effect level:
> 2 000 mg/kg bw
Mortality:
None
Clinical signs:
other: 200 and 2000 mg/kg: piloerection, signs of urinary incontinence, stained tail, coloured urine, coat stained by the test substance and upward curvature of the spine.
Gross pathology:
No macroscopic abnormalities

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No mortalities at any of the doses, the acute oral median lethal dose was therefore > 2000 mg/kg to both male and female rats.