Registration Dossier
Registration Dossier
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EC number: 206-768-5 | CAS number: 373-61-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable non-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Dihydrogen bis(acetato-O)difluoroborate(1-)
- EC Number:
- 206-768-5
- EC Name:
- Dihydrogen bis(acetato-O)difluoroborate(1-)
- Cas Number:
- 373-61-5
- Molecular formula:
- BF3 x (CH3COOH)2
- IUPAC Name:
- bis(acetic acid); trifluoroborane
- Details on test material:
- Name of the test substance used in the study report: Borfluorid-Essigsaeure
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Details on oral exposure:
- The test substance was administered as a 0.928 - 14.7 solution in Lutrol V/V.
- Doses:
- 100, 147, 215, 316, 464, 681, 1000, 1470 ul/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 510 mg/kg bw
- Remarks on result:
- other: original value: ca. 380 ul/kg
- Mortality:
- 100 , 147, 215 ul/kg: no mortalities after 14 days
316 ul/kg: 2/5 males after 14 days
464 ul/kg: 5/5 males and 4/5 females after 14 days
681, 1000 and 1470 ul/kg: all rats died within 14 days - Clinical signs:
- other: Dyspnea, apathy, lateral and ventral position, staggering, partial narcotic-like state with missing pain and cornea reflexes, exsiccosis, diarrhea, poor general state.
- Gross pathology:
- Acute dilatation of the heart, acute congestive hyperemia, dilatation of the stomach with liquid content, extensive ulcerations in the glandular stomach; intestine: diffuse reddened mucosa, atonic, diarrheic content.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
