Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-110-7 | CAS number: 2362-14-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 1.26 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.6
- Remarks on result:
- other: pH given is the average of all determinations from both tests. Range 6.3-6.7 SU.
- Details on results:
- Six samples were analysed in the first run at 0.52 mL/min, and six in the second run at 0.26 mL/min. The quantification was performed by HPLC, and the water solubility of DMBPC at 20 °C was determined to be 1.26 mg/L (± 0.02 mg/L).
- Conclusions:
- The water solubility of the test material at 20 °C was determined to be 1.26 ± 0.02 mg/L.
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions using the column elution method.
The flow rate was adjusted to approximately 30 mL/h (i.e. 0.52 mL/min) in the first experiment. The result obtained was confirmed by a second experiment using half the flow rate of the first experiment (approximately 0.26 mL/min). The column eluate was sampled (six samples/experiment) in time intervals of at least 1 hour to determine the concentration of the test material. Total elution time was 96.5 hours. The quantification was performed by HPLC.
The water solubility of the test material at 20 °C was determined to be 1.26 ± 0.02 mg/L.
Reference
Description of key information
The water solubility was determined to be 1.26 mg/L at 20 °C and pH 6.6.
Key value for chemical safety assessment
- Water solubility:
- 1.26 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions using the column elution method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The flow rate was adjusted to approximately 30 mL/h (i.e. 0.52 mL/min) in the first experiment. The result obtained was confirmed by a second experiment using half the flow rate of the first experiment (approximately 0.26 mL/min). The column eluate was sampled (six samples/experiment) in time intervals of at least 1 hour to determine the concentration of the test material. Total elution time was 96.5 hours. The quantification was performed by HPLC.
The water solubility of the test material at 20 °C was determined to be 1.26 mg/L (± 0.02 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
