Registration Dossier
Registration Dossier
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EC number: 212-406-7 | CAS number: 814-80-2
Endpoint summary
Administrative data
Description of key information
Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
Despite being irritating to abraded rabbit skin, lactic acid is practically non-toxic by the oral, inhalation and dermal route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 290 mg/kg bw
- Quality of whole database:
- Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
1 g lactic acid corresponds to 1.21 g calcium lactate
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 7 400 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 420 mg/kg bw
- Quality of whole database:
- Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
1 g lactic acid corresponds to 1.21 g calcium lactate
Additional information
Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
Lactic acid is a ubiquitous and essential biological molecule. It is, as is to be expected, practically non-toxic by all routes of exposure. Dermal exposure to 2000 mg/kg bw induced severe irritation, but no mortality. Oral administration of doses of 3500 mg/kg bw induce mortality, and lower doses induce clear signs of toxicity. All toxicity signs clearly point to (acid) irritation as the main or only mode of action. At 7400 mg/m3 lactic acid in air, one out of 5 female rats died in a 4 hour inhalation study. All symptoms observed in dead and surviving animals suggest (acid) irritation as the main or only mode of action.Justification for classification or non-classification
Calcium lactate fully dissociates into Ca2+ ions and lactate. The toxicological effects of lactate can be understood in terms of the toxicological effect of lactic acid. Calcium ions - i.e. simple calcium salts, are non-toxic.
Lactic acid is a ubiquitous and essential biological molecule. It is, as is to be expected, practically non-toxic by all routes of exposure.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
