Registration Dossier
Registration Dossier
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EC number: 203-176-9 | CAS number: 104-12-1
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Title:
- No information
- Author:
- Jochheim CM et al. (2002). Glutathione-dependent metabolism|of the antitumor agent Sulofenur. Evidence for the formation|of p-chlorophenylisocyanate as a reactive intermediate.|Chem. Res. Toxicol. 15, 240-248
Materials and methods
- Type of study / information:
- Metabolism of the antitumor agent sulofenur. Evidence for the formation of p-chlorophenyl isocyanate as a reactive intermediate
- Principles of method if other than guideline:
- glutathione and N-acetylcysteine conjugates of p-chlorophenyl isocyanate excreted into bile and urine after an ip dose of sulofenur to rats were examined by mass spectrometry and combined liquid chromatography-tandem mass spectrometry
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorophenyl isocyanate
- EC Number:
- 203-176-9
- EC Name:
- 4-chlorophenyl isocyanate
- Cas Number:
- 104-12-1
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-4-isocyanatobenzene
- Details on test material:
- solufenur (>99% pure) was synthesized at Eli Lilly & Co.
Constituent 1
Results and discussion
Any other information on results incl. tables
RM-Freetext:
Sulofenur is suggested to undergo bioactivation in vivo to
the reactive p-chlorophenyl isocyanate which, in turn, is
trapped in the form of GSH adduct and processed further to
the corresponding N-acetyl-L-cysteine conjugate.
Applicant's summary and conclusion
- Executive summary:
Sulofenur is suggested to undergo bioactivation in vivo to the reactive p-chlorophenyl isocyanate which, in turn, is
trapped in the form of GSH adduct and processed further to the corresponding N-acetyl-L-cysteine conjugate.
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