Registration Dossier
Registration Dossier
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EC number: 931-297-3 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The assessment of the toxicokinetics of HDI oligomers, iminooxadiazindione, is based on read-across of physico-chemical properties and toxicological data of HDI oligomers, isocyanurate. Experimental toxicokinetic studies were not performed.
Data source
Reference
- Reference Type:
- other: Toxicokinetic Assessment
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- assessment on toxicokinetics
Test material
- Reference substance name:
- HDI oligomers, isocyanurate
- IUPAC Name:
- HDI oligomers, isocyanurate
Constituent 1
Results and discussion
Any other information on results incl. tables
For assessment of toxicokinetic properties a read across to HDI oligomers, isocyanurate type (EC 931 -274 -8) is applied. This substance is a close structural analogue to HDI oligomers, iminooxadiazindione type, also derived from catalytic oligomerisation of 1,6 -hexamethylene diisocyanate (HDI; CAS 822 -06 -0) and also belonging to the CAS number 28182-81-2 (Hexane, 1,6 - diisocyanato-, homopolymer).The read across is based on physicochemical and toxicological similarity. In fact, comparison of the toxicological endpoints, that are available for both of the two substances (Acute oral toxicity, Acute inhalation toxicity, Skin and Eye Irritation/Corrosion, Skin Sensitisation, Bacterial mutagenicity (Ames)) reveal good correlation. With respect to Inhalation Toxicity an expert statement is available justifying the read across (Pauluhn, Comparison of pulmonary irritation potency..., Bayer HealthCare AG, 2008).
Therefore, test results obtained for HDI oligomers, isocyanurate type can be transferred to HDI oligomers, iminooxadiazindione type and the toxicokinetic properties of HDI oligomers, isocyanurate type are also valid for HDI oligomers, iminooxadiazindione type. This approach is in accordance with Annex XI, section 1.5 of the REACH Regulation (Regulation (EC) No 1907/2006).
See below the toxicokinetic assessment of HDI oligomers, isocyanurate type.
Applicant's summary and conclusion
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