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EC number: 915-568-3 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Dresinate 835 A has a low water solubility (ca. 40 mg/L at 25 °C) and is lipophilic (partition coefficient n-octanol/water: 0.9 to 6.6 at pH2, 3 to 5.8 at pH7).
An acute dermal toxicity study with the closely related substance Resin 835 A (Reaction mass of Rosin, hydrogenated and [1R-(1a,4aß,10aa)]-1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-1,4a-dimethylphenanthren-1-carboxylic acid)did not reveal adverse effects to the skin nor were systemic effects noted after dermal administration. The LD50 was >2000 mg per kg body weight.
Dresinate 835 A was proven to be bioavailable when administered orally:
In an acute toxicity study, oral administration of Dresinate 835 A (gavage) resulted in mortality at the high dose of 2000 mg/kg body weight. The LD50 was >2000 mg per kg body weight.
The liver was identified as a target organ in subacute and subchronic studies with the closely related substance Resin 835 A (Reaction mass of Rosin, hydrogenated and [1R-(1a,4aß,10aa)]-1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-1,4a-dimethylphenanthren-1-carboxylic acid), at the high dose of 1000 mg/kg body weight and oral gavage administration as aqueous suspensions.
The bioavailability of the test substance was also proven in a development toxicity screening test where another closely related substance (Rosin, CASNR 8050-09-7) was administered orally via the feed. Effects on the number of implants and on litter size were attributed rather to maternal toxicity at ca. 1000 mg/kg body weight than to developmental toxicity.
No indications for adverse effects after metabolisation were derived from genotoxicity studies with Resin 835 A (Reaction mass of Rosin, hydrogenated and [1R-(1a,4aß,10aa)]-1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-1,4a-dimethylphenanthren-1-carboxylic acid), where negative results were obtained without and with the use of a metabolising system.
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