Registration Dossier
Registration Dossier
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EC number: 201-944-8 | CAS number: 89-83-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- monograph
- Author:
- Opdyke et al.
- Year:
- 1 982
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity study
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database, 2017.
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity study in rat
- Author:
- Jay A. Brown
- Year:
- 2 017
- Bibliographic source:
- Haz-Map®
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study of test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Guaiacol
- EC Number:
- 201-964-7
- EC Name:
- Guaiacol
- Cas Number:
- 90-05-1
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 2-Methoxyphenol
- Details on test material:
- Name: 2-MethoxyphenolInChI:1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3Smiles: COc1ccccc1O- Name of test material:Guaiacol- Molecular formula :C7H8O2- Molecular weight :124.1382 g/mol- Substance type:organic- Physical state:Colorless solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 2 h
- Remarks on duration:
- not specified
- Concentrations:
- Range between 2,000 and 17,000 mg/m³
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- - Necropsy of survivors performed: yes- Other examinations performed: Animals were observed for mortality and clinical signs.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 7 570 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 2 h
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: Initially all animals exhibited slight inflammations of the eyes and the respiratory tract as well as agitation, followed by a loss of activity. After exposures to values up to 4,000 mg/m³ these symptoms were reversible after the termination of the exposu
- Body weight:
- not specified
- Gross pathology:
- The dissection revealed injuries in several organs (vascularisation, bleeding, dystrophic changes).
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation toxicity dose (LC50) was considered to be 7570 mg/m³, when mice were exposed to test chemical via inhalation by vapor for 2 hour exposure.
- Executive summary:
The acute inhalation toxicity study was conducted by using test chemical in mice at the concentration range between 2,000 and 17,000 mg/m³. Animals were observed for mortality and clinical signs. Necropsy was performed. 50% mortality was observed in treated mice at 7570 mg/m³ when exposed for 2 hours. Initially all animals exhibited slight inflammations of the eyes and the respiratory tract as well as agitation, followed by a loss of activity. After exposures to values up to 4,000 mg/m³ these symptoms were reversible after the termination of the exposure. Higher concentrations caused further CNS and neuromuscular symptoms (weak reflexes, unsteady gait, respiratory disorders, and tonic-clonic spasms). The dissection revealed injuries in several organs (vascularisation, bleeding, dystrophic changes). Therefore, LC50 was considered to be 7570 mg/m³, when mice were exposed to test chemical via inhalation by vapor for 2 hour exposure.
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