Kerosine (Fischer-Tropsch), full-range, C8-16-branched and linear

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

This endpoint has been reviewed, assessed and accepted by UK-HSE as competent authority for the notification of a new substance [EC number: 481-670-5; Data from UK-Notification Dossier by Shell U.K. Limited in accordance with Directive 92/32/EEC (Articles 7/8/9/12) O.J.L 154, Volume 35, 5 June 1992; Notification Report 06-31-0126-00 from 1st Nov, 2006].

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: review

Title:

Unnamed

Year:

2006

Materials and methods

Test guideline

Qualifier:

no guideline required

Deviations:

not applicable

Principles of method if other than guideline:

The toxicity of the representative chemical components of the substance 'Kerosine (Fischer-Tropsch), full range, C8-16 - branched and linear'
(with linear:branched component ratios of 20:80 and 80:20) to fish have been calculated in accordance with the methods described by Peter Fisk Associates (2006) using QSARs for non-polar narcotics. The QSARs take the form of a generic equation:
log(LC50, EC50 or NOEC) = a log(Kow) + b
where a and b are constants equal to the slope and the intercept on the y axis of the regression equation and Kow is octanol-water partition
coefficient of each component under consideration.

Test material

Test material information

Constituent 1

Reference substance name:

C8-C16 branched and linear hydrocarbons (full range) – Kerosine

Cas Number:

848301-66-6

Molecular formula:

main general molecular formula: CnH(2n+2)

IUPAC Name:

C8-C16 branched and linear hydrocarbons (full range) – Kerosine

Sampling and analysis

Analytical monitoring:

not required

Test organisms

Test organisms (species):

other: not applicable (calculated by QSAR)

Study design

Test type:

other: not applicable (calculated by QSAR)

Water media type:

not specified

Remarks on exposure duration:

not applicable (calculated by QSAR)

Results and discussion

Effect concentrations

Effect concentrations 1

Dose descriptor:

EL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: not applicable (calculated by QSAR )

Effect concentrations 2

Dose descriptor:

NOELR

Effect conc.:

0.008 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: not applicable (calculated by QSAR )

Any other information on results incl. tables

Sublethal observations / clinical signs:

see attached full study report at "5.2.1 Biodegradation in water: screening tests" [ Attachment 8, page 5 -16]

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Remarks:

calculated by QSAR

Conclusions:

Results calculated by QSAR [using the methods described in the report by Peter Fisk Associates (2006)]:
- will not be acutely toxic to fish at a loading rate of 100 mg/l (EL50>100mg/l)
- the substance has a predicted chronic NOEL of 0.008 mg/l to fish
- both predictions are unaffected by the 20:80 and 80:20 ratios of linear:branched components

It is concluded from reviewing test data for the substance, related substances and component substances [reported in the environmental hazard property summary review by Peter Fisk Associates (2006) - see below 'Cross-reference to other study' or Attachment 8] that 'Kerosine (Fischer-Tropsch), full range, C8-16 - branched and linear'
- will not be acutely toxic to fish at a loading rate of 100 mg/l;
- could be chronically toxic to fish at a loading rate of <1.0 mg/l.
It should be noted that the original study reports have not been reviewed.

Classification: The substance should not be classified in the EU for acute toxicity because no effects on fish (or invertebrates or algae) are predicted
at a loading rate of 100 mg/l. Some components are of high log Kow but it is likely that all are rapidly biodegradable. Classification for chronic toxicity on the basis of predicted toxicity to fish (and invertebrates) is negated by the substance being predicted to be readily biodegradable.