Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-883-1 | CAS number: 92878-95-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 14-17 July 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 431 In vitro skin Corrosion: Human skin model test
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
- EC Number:
- 618-883-1
- Cas Number:
- 92878-95-0
- Molecular formula:
- C10H12ClNO4
- IUPAC Name:
- 2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
Constituent 1
Test animals
- Species:
- other: In vitro assay in tissue (EpiDerm Skin Model)
Test system
- Number of animals:
- na
Results and discussion
In vivo
- Other effects:
- The relative mean tissue viability obtained after the 3-minute and 1-hour treatments with WAY-188471 compared to the negative control tissues was 100% and 108% respectively. Because the mean relative tissue viability for WAY-188471 was not below 50% after 3 minutes treatment and not below 15% after 1 hour treatment WAY-188471 is considered to be not corrosive
Any other information on results incl. tables
The relative mean tissue viability obtained after the 3-minute and 1-hour treatments with WAY-188471 compared to the negative control tissues was 100% and 108% respectively. Because the mean relative tissue viability for WAY-188471 was not below 50% after 3 minutes treatment and not below 15% after 1 hour treatment WAY-188471 is considered to be not corrosive
Applicant's summary and conclusion
- Interpretation of results:
- other: not corrosive
- Conclusions:
- Finally, it is concluded that this test is valid and that WAY-188471 is not corrosive in the in vitro skin corrosion test under the experimental conditions described in this report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
