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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Remarks:
Follows standard guidelines, under GLP
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Vehicle:
water
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male 2000 mg/kg bw, number of animals: 5, number of death: 0
Male 5000 mg/kg bw, number of animals: 5, number of death: 2
Female 2000 mg/kg bw, number of animals: 5, number of death: 0
Female 5000 mg/kg bw, number of animals: 5, number of death: 2
Clinical signs:
other: Signs of toxicity related to dose levels: Death were observed between 5 hours and 2 days after dosing. Pilo-erection, hunched posture, abnormal gait, lethargy, decreased respiratory rate and pallor of the extremities were observed in both sexes at both d
Gross pathology:
Effects on organs: no macroscopic findings were observed in any animals surviving treatment. Congestion of blood vessels of the small and large intestines was observed in one female which died following 5000 mg/kg.
Interpretation of results:
not classified
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Remarks:
Follows standard guidelines, under GLP
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes
Limit test:
yes
Species:
rat
Sex:
male/female
Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24h
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 380 mg/kg bw
Mortality:
Male 2380 mg/kg bw: number of animals: 5, number of deaths: 0
Female 2380 mg/kg bw: number of animals: 5, number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: no treatment-related macroscopic findings were observed.
Interpretation of results:
not classified
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 380 mg/kg bw

Additional information

Justification for classification or non-classification