Registration Dossier
Registration Dossier
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EC number: 266-124-4 | CAS number: 66085-00-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on microorganisms up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the toxicity of Glycerol monoisostearate (CAS 66085-00-5)
to aquatic microorganisms are not available.
The assessment was therefore based on studies conducted with the
structurally similar substance 1,2,3-propanetriyl trioleate (CAS
122-32-7) as part of a read across approach, which is in accordance with
Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is
given within the overall summary chapter 6.1 and within the analogue
justification section 13.
The toxicity of 1,2,3-propanetriyl trioleate (CAS 122-32-7) to aquatic microorganisms was tested according to the German method Assessment of hazardous substances in water, Determination of the acute toxicity in Bacteria, under GLP conditions (Coenen, 1988). Pseudomonas putida cultures were exposed to the test substance for 18 hours in a static water regime at 25°C and effects on cell proliferation assessed (as the extinction of the monochromatic radiation at 436 nm in a 10 mm layer). After the exposure period, no inhibitory effects on cell multiplication could be observed up to the highest concentration tested and therefore, the EC50 (18 h) was determined to be > 0.8 mg/L (nominal concentration). Thus, no toxicity up to the limit of water solubility of 1,2,3-propanetriyl trioleate (< 0.05 mg/L) was observed. Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on aquatic microorganisms are expected up to the limit of water solubility for Glycerol monoisostearate (CAS 66085-00-5).
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