Registration Dossier
Registration Dossier
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A mixture of: 4-(2,2,3-trimethylcyclopent-3-en-1-yl)-1-methyl-2-oxabicyclo[2.2.2]octane; 1-(2,2,3-trimethylcyclopent-3-en-1-yl)-5-methyl-6-oxabicyclo[3.2.1]octane; spiro[cyclohex-3-en-1-yl-[(4,5,6,6a-tetrahydro-3,6',6',6'a-tetramethyl)-1,3'(3'aH)-[2H]cyclopenta[b]furan]; spiro[cyclohex-3-en-1-yl-[4,5,6,6a-tetrahydro-4,6',6',6'a-tetramethyl)-1,3'(3'aH)-[2H]cyclopenta[b]]furan]
EC number: 422-040-1 | CAS number: 426218-78-2 CASSIFFIX
Bioaccumulation: terrestrial
Administrative data
Link to relevant study record(s)
Description of key information
The BCF for terrestrial organisms is calculated using the QSAR of Jager (1998) incorporated in the EUSES model using a value of 4.72 yielded a value of 631 L/kg ww.
Key value for chemical safety assessment
- BCF (terrestrial species):
- 631 L/kg ww
Additional information
Bioaccumulation for air-breathing organism is based on available information of Log Koa, persistency information, identification of the key degradation product and anticipated metabolism. The Koa for Cassiffix exceeds the cut off criterion of 5. The substance is considered persistent. In this biodegradation study Cassiffix-Lactone has been the key metabolite including a reduction into a double bond in the same ring as the lactone. This metabolite is also anticipated to be the key metabolite in organisms being a simple oxidation and reduction, respectively. This metabolite may be excreted as such via the kidneys based on its log Kow of 3. It is more likely that this lactone will be reduced into an alcohol or de-esterified resulting in an acid and an alcohol and subsequently conjugation in the Phase 2 metabolic pathway. Via this pathway the kidneys will be the key excretion route as is seen in the repeated dose toxicity studies. Air is therefore not the key excretion route (e.g in contrast to fish) and therefore there is no concern for air-breathing organisms. This is explained in more detail by Gobas et al. (2020). They present that Oxygen containing chemicals are unlikely a concern for air-breathing organisms, because of their metabolism and kidneys being the key excretion pathways (see Toxico-kinetic section for more details).
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