Registration Dossier
Registration Dossier
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EC number: 210-959-9 | CAS number: 626-67-5
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Relevant methodological deficiencies.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice.
- Author:
- Schafer, E.W., Bowles, W.A.
- Year:
- 1 985
- Bibliographic source:
- Arch. Environm. Contam. Toxicol. 14, 111-129.
Materials and methods
- Principles of method if other than guideline:
- Animals were given wheat seeds endowed with N-Methyl Piperidine for 3 days. One percent of the seeds was not ingested after 3 days, which was taken as food reduction value. An LD-value was calculated based on the mean weight of the ingested seeeds (50 mg) and the mean weight of the animals. No details were available for mortality rates and clinical signs during the test period.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- N-Methyl Piperidine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: deer mice
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Details on oral exposure:
- Animals were given 25 wheat seeds endowed with 2% (W/W) N-Methylpiperidine for 3 days in addition to a standard pellet diet. One percent of the seeds was not ingested after 3 days, which was taken as food reduction value. An LD-value was calculated based on the mean weight of the ingested seeds (50 mg) and the mean weight of the animals. No details were available for mortality rates and clinical signs during the test period.
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- continuous with feed
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2% (W/W)
Basis:
nominal in diet
- No. of animals per sex per dose:
- 5 animals
- Details on study design:
- Post-exposure period: 4 Tage
Results and discussion
Results of examinations
- Details on results:
- Less than 50% of the animals died after ingestion of 1238 mg/kg bw/day. No more details were given regarding clinical signs or mortality rates.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
