Registration Dossier
Registration Dossier
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EC number: 231-912-9 | CAS number: 7778-74-7
Endpoint summary
Administrative data
Description of key information
Acute toxicity data are available for the oral and inhalation routes of exposure, but are non-standard and unsuitable for the purposes of classification. Acute dermal toxicity is predicted to be low due to the very low likely dermal absorption.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Two non-standard studies are available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Dose descriptor:
- LC50
- Value:
- 80 000 mg/m³ air
- Quality of whole database:
- One non-standard study is available. Animals were exposed to a pyrotechnically generated atmosphere, the relevance of this to the submission substance is unclear.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity data are unsuitable for the purposes of classification. A dietary study in the mouse (Gauss, 1972 reported in ATSDR, 2008) reports an LD50 value of 3621 mg/kg bw; deaths were reported within 4 days. A drinking water study in the rat did not report any mortality follwoing treatment for 4 days at concentrations of up to 500 mg/L (estimated to be equivalent to 50 mg/kg bw). It is noted that that potassium perchlorate is listed on Annex VI of the CLP Regulation and is classified for acute oral toxicity in Category 4 (H302); DPD (R22) 'Harmful if swallowed'.
An acute inhalation toxicity study was perfomred in Fischer 344 rats exposed to the resulting aerosols from the pyrolysis of Spectrex Fire Extinguishant (SFE) Formulation A, a pyrotechnically generated aerosol fire suppressant, at a loading 50 or 80 g/m3 air for 15 or 60 minutes. No deaths occurred in this study, indicating low acute inhalation toxicity. Animals were exposed to a pyrotechnically generated atmosphere, the relevance of this to the submission substance is unclear.
Justification for selection of acute toxicity – oral endpoint
Available data are not adequate for classification
Justification for classification or non-classification
Available data are inadequate or unsuitable for the purposes of classification; however the substance is listed on Annex VI of the CLP Regulation and is classified for acute oral toxicity in Category 4 (H302).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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