Registration Dossier
Registration Dossier
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EC number: 930-389-0 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 10, 2007 - June 18, 2007
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- , 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- , 1992
- Deviations:
- no
- Principles of method if other than guideline:
- NaNO3 instead of an organic substance was used for the determination the dead time, because NaNO3 as a small inorganic molecule has less interaction on a reversed phase chromatographic column than organic substances. This was confirmed by our experience with this method. Due to technical reasons, standards were injected separately instead of simultaneously.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2006-06-01
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Symrose
- Substance type: technical product
- Physical state: colourless, liquid
- Storage condition of test material: ambient air, dark and dry
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 4.49
- Temp.:
- 24 °C
- pH:
- 6
- Details on results:
- The test temperature was within the range of 23.8 – 24.5 °C. The HPLC dead time (t0) was determined by threefold injection of a solution of 1 mg/L sodium nitrate and was determined to 0.526 min (mean).
Any other information on results incl. tables
Table1: Retention times, Capacity factors and estimated Partition Coefficient of Symrose
Test item |
Retention time (min) |
Capacity factor |
log (capacity factor) |
log POW |
Symrose |
5.430 |
9.323 |
0.970 |
4.49 |
5.420 |
9.304 |
0.969 |
4.49 |
|
5.402 |
9.270 |
0.967 |
4.48 |
|
5.395 |
9.257 |
0.966 |
4.48 |
|
Mean |
4.49 |
|||
Applicant's summary and conclusion
- Conclusions:
- The logPow of the test item Symrose was calculated at 4.49 at pH 6
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