Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 696-364-9 | CAS number: 133779-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 19.3 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1.48 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 1.93 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 2.19 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 1.72 mg/kg sediment dw
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 172 µg/kg sediment dw
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 10 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 89 µg/kg food
- Assessment factor:
- 90
Additional information
As long-term NOECs from species representing two trophic levels are available (algae and daphnia) and these results cover the level showing the lowest EC50 in short term tests, an assessment factor of 50 may be used. However based on the observed lower toxicity to fish not only for the alkyl-1,3 -diaminopropanes but also for primary fatty amines and mono and dialkyl quats it is considered unlikely that fish toxicity will be critical for alkyl-1,3 -diaminopropanes. Hence any additional toxicity testing with fish will not add scientific value to the ecotoxicity profile of the alkyl-1,3-diaminopropanes other than for obtaining a lower assessment factor. It is therefore concluded that for scientific reasons and in accordance to REACH legislation further testing on fish has to be avoided for reasons of animal welfare and that based on the weight of evidence available on ecotoxicity data for several cationic surfactants the use of safety factor of 10 is justified for the derivation of the PNECaquatic,bulk.
The PNECsediment and the PNECsoil are derived on the basis of experimental data and the application of the appropriate assessment factor according to REACH guidance.
For classification purposes Ecotoxicity, Biodegradability and Bioconcentration have to be considered
Ecotoxicity
Due to intrinsic properties of amine containing cationic surfactants river water ecotoxicity tests deliver reproducible test results with limited uncertainty. As river water has a mitigating effect on ecotoxicity due to sorption of the amines toand suspended matter a factor of 10 should be applied to the L(E)C50to correct for the lower ecotoxicity observed. Algae are in general the most sensitive species and are therefore for most of the alkyl-1,3-diaminopropanes basis for classification. It should be noted that the 21 day daphnia EC50 is included in the table below for classification purposes as a worst-case in the absence of 48 day EC50values.
Table.Available algae and chronic daphnia test results for the alkyl-1,3-diaminopropanes
Alkyl-1,3-diaminopropanes |
CAS number |
72 h algae ERC50(µg/L) |
21 d daphnia EC50 (µg/L) |
EC50corr(µg/L) (corrected for Classification with Factor 10) |
Amines, N-tallow alkyltrimethylenedi- |
61791-55-7 |
596 |
566 |
56.6 |
Amines, N-(hydrogenated tallow alkyl)trimethylenedi- |
68603-64-5 |
596 |
566 |
56.6 |
Amines, N-coco alkyltrimethylenedi- |
61791-63-7 |
65.2 |
96.8 |
6.5 |
(Z)-N-9-octadecenylpropane-1,3-diamine |
7173-62-8 |
214 |
290 |
21.4 |
Amines, N-C12-14-alkyltrimethylenedi- |
90640-43-0 |
65.2 |
179 |
6.5 |
Figures given in bold are based on read across.
Biodegradability
Based on the available studies on biodegradation, the substances are estimated to be readily biodegradable. The 10-days-window criterion does not need to be evaluated for the cationic surfactants under consideration as they are UVCB substances.
Bioconcentration factor
No measured BCF for fish is available. Standard OECD 305 tests are technically not feasible with the strongly sorbing easily biodegradable substances. The log Kow values provided in the dossier are however acceptable. The BCF was therefore calculated using the BCFBAF v3.0 estimation program as included in EPIweb v4.0. In addition based on information of kinetics in mammals and for n-hexadecyl amine in fish and the general properties of surfactants, a high bioaccumulation potential is not expected.
Table. Measured log Kow values for alkyl-1,3,diaminopropane technical products and the calculated log BCF based on the measured log Kow.
Alkyl-1,3-diaminopropanes |
CAS number |
Slow stirring log Kow |
Calculated Log BCF (EPI v4.0) |
Amines, N-tallow alkyltrimethylenedi- |
61791-55-7 |
1.5 |
0.5 |
Amines, N-(hydrogenated tallow alkyl)trimethylenedi- |
68603-64-5 |
1.5 |
0.5 |
Amines, N-coco alkyltrimethylenedi- |
61791-63-7 |
-0.6 |
0.5 |
(Z)-N-9-octadecenylpropane-1,3-diamine |
7173-62-8 |
0.0 |
0.66 |
Amines, N-C12-14-alkyltrimethylenedi- |
90640-43-0 |
-0.6 |
0.5 |
Conclusion on classification
Classification according(Classification, Labeling & Packaging Directive 1272/2008/EC)
As all acute ecotoxicity values (corrected and uncorrected) as given the Table above are below 1 mg/L but the diamines are ‘readily biodegradable’ and have a low bioaccumulation potential based on the measured log Kow values.
This leads to an environmental classification according for alkyl-1,3-diaminopropanes:
Acute (short-term) aquatic hazard Acute Category 1
The corresponding M-factor is 10 based on the EC50 of 56.6 µg/L (21 d EC50 parental daphnia of 566 µg/L and applying an additional correction factor of 10 for mitigation )
M factor 10
When chronic toxicity data are available these should be used for classification for chronic aquatic hazard. Considering the lower sensitivity of fish it is considered justified to use the long-term daphnia and algae test results for the chronic classification. Alkyl-1,3 -diamines are readily biodegradable and the lowest NOEC/EC10 is 193 µg/L. Correcting this value for mitigation with the realistic worst-case correction factor of 10 leads to NOEC/EC10 for classification of 19.3 µg/L. The corresponding M-factor is 1
Chronic(Long-term) aquatic hazard Chronic Category 2
M factor 1
Classification according DSD (Dangerous Substance Directive 67/548/)
As all ecotoxicity values (corrected and uncorrected) as given in Table 32 are below 1 mg/L. Based on these results it is proposed to classify the alkyl-1,3-diaminopropanes asR50.
Alkyl-1,3-diaminopropanes are readily biodegradable. The measured log Kow <3 and calculated BCF <100 L/kg which means that anR53does not need to be assigned.
This leads to the following environmental classification according DSD for the five alkyl-1,3-diaminopropanes
N, R50
For preparations corresponding M factors should be applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.