Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Inorganic lead compounds do not exhibit toxicity in acute toxicity tests with experimental animals.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw
Quality of whole database:
good

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Justification for classification or non-classification

The current classification of lead compounds not otherwise described in Annex VI to CLP is:

  • Acute Tox. 4 *                       (H332)
  • Acute Tox. 4 *                       (H302)

Existing classifications for acute toxicity are not supported by the existing data or read across. Acute toxicity is not observed in animals after oral, inhalation or dermal exposures, up to the limit values of acute toxicity testing, for lead oxide. Acute toxicity is not observed in animals after oral exposures up to the limit values of acute toxicity testing for six different similar inorganic lead compounds.  Two similar compounds are also lacking in dermal toxicity and in irritancy properties for the skin or eyes. Although toxic under chronic exposure situations, the acute toxicity of this substance is low and does not require classification.