Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Nanomaterial aspect ratio / shape
Administrative data
- Endpoint:
- nanomaterial aspect ratio/shape
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Type of method:
- transmission electron microscopy
- Details on methods and data evaluation:
- The substance was suspended in ethanol and sonicated for 15 minutes. This stock solution was then diluted 10 times with ethanol to achieve an analytical concentration equivalent to 0.1 mg/mL. An aliquot of this analytical solution was collected under sonication then immediately deposited on a graphene covered Cu TEM grid with a filter paper underneath and left to dry in the air for 10 minutes, prior to analysis by TEM.
The particle size distributions of the major and minor axis of 1125 primary particles were measured using TEM data for the test substance. An aspect ratio distribution was determined from this data and the median aspect ratio calculated.
30 nm gold nanoparticles were analysed as a reference material to ensure the instrumentation and methodology was functioning as expected.
Test material
- Reference substance name:
- Not applicable
- IUPAC Name:
- Not applicable
- Reference substance name:
- Calcium oxide
- EC Number:
- 215-138-9
- EC Name:
- Calcium oxide
- Cas Number:
- 1305-78-8
- Molecular formula:
- CaO
- IUPAC Name:
- oxocalcium
- Reference substance name:
- Quartz (SiO2)
- EC Number:
- 238-878-4
- EC Name:
- Quartz (SiO2)
- Cas Number:
- 14808-60-7
- Molecular formula:
- SiO2
- IUPAC Name:
- Quartz
- Reference substance name:
- Zinc sulphide
- EC Number:
- 215-251-3
- EC Name:
- Zinc sulphide
- Cas Number:
- 1314-98-3
- Molecular formula:
- SZn
- IUPAC Name:
- thioxozinc
- Reference substance name:
- Silicon dioxide
- EC Number:
- 231-545-4
- EC Name:
- Silicon dioxide
- Cas Number:
- 7631-86-9
- Molecular formula:
- O2Si
- IUPAC Name:
- Silicon dioxide
- Reference substance name:
- Carbon black
- EC Number:
- 215-609-9
- EC Name:
- Carbon black
- Cas Number:
- 1333-86-4
- Molecular formula:
- C
- IUPAC Name:
- Carbon black
- Test material form:
- solid: nanoform
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Data gathering
- Instruments:
- JEOL200CX transmission electron microscope
- Calibration:
- Calibration was conducted using freshly synthesised 30 nm gold nanoparticles as a reference. The major (36.9 nm) and minor (31.9 nm) particle axis size distribution and median value was determined, alongside the aspect ratio.
Results and discussion
Shape description
- Key result
- Shape:
- spherical
- Percentage:
- 100 %
Aspect ratio
- Key result
- x Dimension:
- 36.27
- St. dev.:
- 4.82
- y Dimension:
- 31.73
- St. dev.:
- 3.81
- Remarks on result:
- other: A median aspect ratio of 1.14 was determined using the median particle size on the major (36.27 nm) and minor (31.73 nm) particle axis.
Applicant's summary and conclusion
- Conclusions:
- A median aspect ratio of 1.14 was determined using the median particle size on the major (36.27 nm) and minor (31.73 nm) particle axis.
This aspect ratio means that the particles fall into the spheroidal shape category. - Executive summary:
The aspect ratio distribution for the test substance was determined using the major and minor particle axis size distributions as determined using TEM analysis. 30 nm gold nanoparticles were analysed as a reference material to ensure the instrumentation and methodology was functioning as expected.
The substance was suspended in ethanol and sonicated for 15 minutes. This stock solution was then diluted 10 times with ethanol to achieve an analytical concentration equivalent to 0.1 mg/mL. An aliquot of this analytical solution was collected under sonication then immediately deposited on a graphene covered Cu TEM grid with a filter paper underneath and left to dry in the air for 10 minutes, prior to analysis by TEM.
A median aspect ratio of 1.14 was determined using the median particle size on the major (36.27 nm) and minor (31.73 nm) particle axis.
This aspect ratio means that the particles fall into the spheroidal shape category.
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