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Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21-28 November 2012

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. Accuracy is limited by measuring range and extrapolation. Therefore validation applies with restrictions.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

23. Mar. 2006

Deviations:

yes

Remarks:

measured at 30 and 45 °C only ; result at 45°C slighlty out of recommended working range

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

Regulation (EC) N°440/2008, as modified by Reg.(EC) No 761/2009

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: Knudsen cell

Specific details on test material used for the study:

- Appearance: White powder
- Storage condition: Test item was stored in a closed vessel at room temperature away from light and humidity.

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0.095 Pa

Key result

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

0.19 Pa

The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):

 

Table 4.6/1: Experimentally Determined Vapour Pressures

T (°C)	T (K)	VP (Pa)	Stand. Dev. (Pa)	RSD (%)
30	303.2	0.386	0.0312	8.1
45	318.2	2.66	0.0712	2.7

For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

log (VP) = -5387.8 x (1/T) + 17.3562

 

Table 4.6/2: Calculated Vapour Pressures at ambient Temperature

Vapour pressure at 20 °C:	9.49 * 10^-02= 0.0949 Pa
Vapour pressure at 25 °C:	1.93 * 10^-01= 0.193 Pa

 

As only two temperatures could be evaluated, the linear regression of log P vs. 1/T gave a correlation coefficient r of - 1.0000. The highest relative standard deviation was lower than 10%. All measured values of the two evaluated experiments show good reproducibility, giving maximum relative standard deviations of less than 10%. Therefore, the result of the test can be considered valid.

Conclusions:

Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).

Executive summary:

The vapour pressure of test item was measured under GLP according to OECD 104 / EU A4 guideline, effusion method with Knudsen cell (weight loss).

 

Determinations were conducted at 30 °C and 45 °C, with triplicate measurements for each of the four cells.

 

The vapour pressures of test item at 20 °C and 25 °C was extrapolated from the regression as 0.095 Pa and 0.19 Pa, respectively.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:

0.19 Pa

at the temperature of:

25 °C

Additional information

A reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Despite restrictions due to technical inaccuracy, it is considered as key study, and the result is retained as key data.