Registration Dossier
Registration Dossier
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EC number: 209-924-0 | CAS number: 598-22-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August - November - 2005
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Propionyl bromide
- EC Number:
- 209-924-0
- EC Name:
- Propionyl bromide
- Cas Number:
- 598-22-1
- Molecular formula:
- C3H5BrO
- IUPAC Name:
- propanoyl bromide
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Doses:
- 300 & 2000 mg/Kg
- No. of animals per sex per dose:
- 6 & 3
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None at 300 mg/Kg, all at 2000 mg/Kg
- Clinical signs:
- Signs of systemic toxicity noted in animals treated at a dose level of 2000 mg/kg were prostration,
noisy and gasping respiration, decreased respiratory rate, pallor of the extremities, increased salivation, hunched posture, lethargy, ataxia and hypothermia.
There were no signs of systemic toxicity noted in animals treated at a dose level of 300 mg/kg. - Body weight:
- The surviving animals showed expected gains in bodyweight over the study period.
- Gross pathology:
- Abnormalities noted at necropsy of animals that died or were killed in extremis during the study were patchy pallor of the liver, haemorrhagic stomach, haemorrhage, ulcerated, epithelial sloughing, thickened or pale non-glandular region of the stomach, haemorrhage, ulcerated, epithelial sloughing, thickened or pale gastric mucosa and haemorrhagic or pale small and large intestines. No abnormalities were noted at necropsy of animals that were killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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