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Diss Factsheets
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EC number: 204-602-6 | CAS number: 123-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- An Evaluation of the Utility of Four in Vitro Short Term Tests for Predicting the Cytotoxicity of Individual Compounds Derived from Tobacco Smoke
- Author:
- Curvall M, Enzell CR and Pettersson B
- Year:
- 1 984
- Bibliographic source:
- Cell Biol Toxicol 1: 173 - 193
- Reference Type:
- publication
- Title:
- Effects of Tobacco and Tobacco Smoke Constituents on Cell Multiplication in Vitro
- Author:
- Pilotti A, Ancker K, Arrhenius E and Enzell C
- Year:
- 1 975
- Bibliographic source:
- Toxicology 5: 49 - 62
- Reference Type:
- publication
- Title:
- Effect of Tobacco Smoke Compounds on the Plasma Membrane of Cultured Human Lung Fibroblasts
- Author:
- Thelestam M, Curvall M and Enzell CR
- Year:
- 1 980
- Bibliographic source:
- Toxicology 15: 203 - 217
- Reference Type:
- publication
- Title:
- Effects of Tobacco Smoke Compounds on the Cilliary Activity of the Embryo Chicken Trachea in Vitro
- Author:
- Petterson B, Curvall M and Enzell CR
- Year:
- 1 982
- Bibliographic source:
- Toxicology 23: 41-55
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test substance cytotoxicity was accessed by evaluating its capacity to inhibit culture growth in ascites sarcoma BP8 cells, to inhibit of the oxidative metabolism in isolated brown fat cells, to increase the permeability of the membranes in human lung fibroblasts, or to increase the time to ciliostasis in the tracheas of unbom chickens.
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Anisaldehyde
- EC Number:
- 204-602-6
- EC Name:
- Anisaldehyde
- Cas Number:
- 123-11-5
- Molecular formula:
- C8 H8 O2
- IUPAC Name:
- 4-methoxybenzaldehyde
- Details on test material:
- - Name of test material (as cited in study report): p-anisaldehyde
No further details provided
Constituent 1
Results and discussion
Any other information on results incl. tables
Cytotoxicity values for the test substance were obtained in four in vitro short term test systems. The mean activity of the results from the four test systems in a 10-point scale was determined as 0.8 (1 for cell growth inhibition in Ascites sarcoma BP 8 cells, 2 for inhibition of the oxidative metabolism in hamster brown fat cells, 0 for membrane damage of human diploid embryonic lung fibroblasts, 0 for inhibition of ciliary activity using chicken embryo trachea).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.