Registration Dossier
Registration Dossier
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EC number: 217-915-8 | CAS number: 2008-39-1
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Dimethylammonium 2,4-dichlorophenoxyacetate may exert acute toxicity to terrestrial arthropods. However, chronic effects caused by this substance are not expected
Key value for chemical safety assessment
Additional information
Two studies determined the acute oral and contact toxicity of dimethylammonium 2,4-dichlorophenoxyacetate (CAS No. 2008-39-1) to honey bees (Klimach, 1995; Irzyk, 2004). The key study was conducted according to the Hygienic-Toxicological Requirements for Pesticides Registration inand, Method No 12 (1976). The test material was administered orally and via dorsal contact, leading to LD50s of 12.4 µg test substance (corresponding to 6.2 µg a.i. per animal) and > 1000 µg test substance (497.5 µg a.i. per animal) respectively.The results from the supporting study showed no adverse effects in survival of honey bees under similar test conditions.
The chronic effects of dimethylammonium 2,4-dichlorophenoxyacetate were investigated in two extended laboratory assays (Hirth, 2006). Both studies were conducted according to ESCORT Guidance documents I and II (Barret, 1994; Candolfi, 2001), under GLP conditions. No significant effects were observed on survival or reproduction of Chrysoperla carnea or Coccinella sectempunctata after 27 and 40 days of exposure to the test material respectively. Thus, a LR50 value could not be determined and it is assumed to be greater than 3 L test substance/ha (2.4 mg a.i./kg dry weight soil).
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