Registration Dossier
Registration Dossier
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EC number: 209-708-6 | CAS number: 591-22-0
Endpoint summary
Administrative data
Description of key information
The substance shows acute toxicity by the oral, inhalation and dermal routes of exposure in experimental in vivo studies.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 500 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 2 900 mg/m³ air
- Quality of whole database:
- adequate. LC50 is less than 2970 mg/m3 (2.97 mg/L or 675 ppm).
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 001 mg/kg bw
- Quality of whole database:
- adequate. LD50 is likely greater than 1000 mg/kg bw.
Additional information
The acute oral LD50 in rats is greater than 50 and less than 500 mg/kg bw. Nine of 10 animals survived the dose of 50 mg/kg bw, while 2 of 10 animals survived the high dose of 500 mg/kg bw. The LD50 is likely less than 300 mg/kg bw. The acute inhalation LC50 in rats is greater than 264 ppm (1.16 mg/L) and less than 675 ppm (2.97 mg/L). Eight of 10 animals survived the 264 ppm dose, while none survived the high dose of 675 ppm. The LC50 is difficult to estimate but is considered to be over 500 ppm. The acute dermal LD50 in rats is less than 2000 mg/kg bw. Two of two female rats died within 1 hour of dermal dosing. The likely LD50 point estimate is greater than 1000 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
Experimental result in guideline study by GLP
Justification for selection of acute toxicity – inhalation endpoint
Experimental result in a guideline study by GLP
Justification for selection of acute toxicity – dermal endpoint
Experimental result in a reliable laboratory
Justification for classification or non-classification
The acute oral LD50 is less than 300 mg/kg bw. This places the substance in Category 3 for acute oral toxicity (50 to 300 mg/kg bw) according to Regulation EC No. 1272/2008.
The acute inhalation LC50 is estimated to be slightly higher than 500 ppm. This places the substance in Category 3 for acute inhalation toxicity (500 to 2500 ppm) according to Regulation EC No. 1272/2008.
The acute dermal LD50 is estimated to be higher than 1000 mg/kg bw but less than 2000 mg/kg bw. This places the substance in Category 4 for acute dermal toxicity (1000 to 2000 ppm) according to Regulation EC No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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