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EC number: 202-548-8 | CAS number: 96-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Phototransformation in air :
The atmospheric oxidation half-life of 5-nitrosalicylic acid was estimated using the level III multimedia model. It was estimated that the substance is persistent in air medium as the half life period of 5-nitrosalicylic acid in air is 7.1 days. This indicates that 5-nitrosalicylic acid is not rapidly phototransformed in air.
Hydrolysis :
The Hydrolysis rate constant of 5-nitrosalicylic acid is estimated to be 0.0000000000197924 (19.7924 E-1 )cm3/molecule-sec. at half life of the 6.485 hrs.The estimated half life of the substance indicates that the substance is moderately hydrolysable.
Phototransformation in water
No experimental data available. As this study is not a standard information requirement in REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance (Annex X requirement), no further testing is considered necessary.
Phototransformation in soil
No experimental data available. As this study is not a standard information requirement in REACH and there is no indication from the CSA on the need to investigate further the fate and behaviour of the substance (Annex X requirement), no further testing is considered necessary.
Biodegradation
Biodegradation in water :
No. of studies of target substance5-nitrosalicylic acidreviewed for Biodegradation in water: screening tests from reliable sources having Klimisch rating 2.
The summary of the results are presented below
Sr.No |
Endpoint |
Half life |
Parameter |
Sources |
1 |
ready biodegradability |
50% degradation in 15 days |
Test mat. analysis |
Predicted data from PBT profiler |
2 |
ready biodegradability |
51.66% degradation |
O2 consumption |
Predicted data from QSAR |
By applying weight of evidence approach the target chemical found to be readily biodegradable with 50% to 51.66% percentage degradation.Thus it is concluded that 5-nitrosalicylic acid is biodegradable in water.
Biodegradation in water and sediment :
Based on the Level III Fugacity Model, the half life period of the 5-nitrosalicylic acid was estimated. The half period of 5-nitrosalicylic acid in water is 15 days (360 hrs) therefore it is considered that the substance will qualify as not persistent as the half life does not exceed the EPA criteria of 60 days. So, it can be confirmed that the substance is readily biodegradable in water medium where as in sediment the half life is 140 days (3360 hrs).
Based on this value, it can be inferred that the substance is persistent in sediment medium and is not readily biodegradable probably due to the anaerobic conditions existing in most sediments. However, it can be observed that 5-nitrosalicylic acid does not diffuse in the sediment medium since it's percentage in the sediment medium is reported to be 0% and hence persistence in the sediment compartment is not likely to be critical.
Media |
Half-Life (days) |
Percent in |
Water |
15 |
24% |
Sediment |
140 |
0% |
Biodegradation in soil :
No. of studies of target substance5-nitrosalicylic acidreviewed for Biodegradation in soil from reliable sources having Klimisch rating 2.
The summary of the results are presented below
Sr.No |
Endpoint |
Half life |
Parameter |
result |
Sources |
1 |
ready biodegradability |
30days |
Test mat. analysis |
biodegradable |
Predicted data from PBT profiler and EPI suite |
2 |
ready biodegradability |
28.399 days |
DT50(Dissipation time) |
biodegradable |
Predicted data from QSAR |
By applying weight of evidence approach the target chemical found to be readily biodegradable with half life 28.399 to 30 days. does not exceeds the threshold (60 days) of being persistent in soil Thus it is concluded that 5-nitrosalicylic acid is biodegradable in soil.
Bioaccumulation
Bioaccumulation is the process by which the chemical concentration in an aquatic organism achieves a level that exceeds that in the water, as a result of chemical uptake through all possible routes of exposure. The relationship between bioaccumulation and bio-concentration is that, chemicals that have the potential to bioconcentrate also have the potential to bioaccumulate. Bioaccumulation is closely related to the Bioconcentration factor (BCF).
The estimated BCF of 5-nitrosalicylic acid in the key study was obtained to be 3.2. Supporting studies indicate the BCF to be between 1.0 to 30.1. This low value of BCF of 5-nitrosalicylic acid indicates its non bioaccumulative nature as the BCF factor is less than the bio-concentration threshold of 1000.
Transport and distribution
Adsorption / desorption :
Soil Adsorption Coefficient i.e Koc value of 5-nitrosalicylic acid was estimated as 549.3 L/kg by means of MCI method. This indicates that 5-nitrosalicylic acid will have a moderate tendency of sorption to soil and have slow migration potential to groundwater.The Koc value at 20 degC is equivalent to a value of 439.44.
Henry's Law constant :
Henry's Law states that at a constant temperature, the amount of a given gas that dissolves in a given type and volume of liquid is directly proportional to the partial pressure of that gas in equilibrium with that liquid. Henrys Law Constant of 5-nitrosalicylic acid at 25 deg C is 0.097 Pa m³/mol.
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