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Environmental fate & pathways

Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2021-02-08 to 2021-02-26
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge
Radiolabelling:
no
Test temperature:
Column temperature: 25°C
Details on study design: HPLC method:
EQUIPMENT
- Apparatus: HPLC System Agilent 1100 series: HPLC pump G1311A, autosampler G1313A, column oven G1316A, degasser G1322A
- Type, material and dimension of analytical (guard) column: Stationary phase: Zorbax Eclipse XDB-CN, Agilent; Particle size: 3.5 pm, pore size: 80 µm; Material: stainless steel, dimensions: 100 mm x 4.6 mm, Serial No.: USBAB01223
- Detection system: variable wavelength detector G1314A (210 nm; 254 nm: calibration substances; 294 nm: test item)
- Flow rate: 0.6 mL/min.

MOBILE PHASES
- Type: Potassium dihydrogen phosphate buffer solution (0.05 mol/l)/ACN 45:55 % (v/v), pH = 7.4, isocratic elution
- Type: Citrat buffer solution (0.05 mol/l)/ACN 45:55 % (w/v), pH = 5.5, isocratic elution

DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column - formamide

REFERENCE SUBSTANCES
- Identity: Acetanilide (CAS # 103-84-4); Atrazin (CAS # 1912-24-9); Triadimenol (CAS # 55219-65-3); Linuron (CAS # 330-55-2); Pyrazophos (CAS # 13457-18-6); Diclofop-methyl (CAS # 51338-27-3); 4,4' DDT (CAS # 50-29-3)

DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 µL ; 0.43 µg (pH 7.4); 0.30 µg (pH 5.5)
- Quantity of reference substances: 10 µL; Calibration substances: 0.96—1.11 µg

REPETITIONS
- Number of determinations: duplicate

EVALUATION
- Calculation of capacity factors k': refer to "Any other information on materials and methods incl. tables" below
- Calculation of retention times: refer to "Any other information on materials and methods incl. tables" below
- Determination of the log Koc value: refer to "Any other information on materials and methods incl. tables" below
Key result
Type:
Koc
Value:
ca. 2 512 dimensionless
pH:
5.5
Temp.:
25 °C
Type:
Koc
Value:
ca. 631 dimensionless
pH:
7.4
Temp.:
25 °C
Type:
log Koc
Value:
2.8 dimensionless
pH:
7.4
Temp.:
25 °C
Type:
log Koc
Value:
3.4 dimensionless
pH:
5.5
Temp.:
25 °C
Validity criteria fulfilled:
yes
Conclusions:
The log Koc value of N-(4-((4-(3-phenyIureido)phenyI)suIfonyI)phenyI)benzenesuIfonamide at pH 7.4 (ionised form) was 2.8 (Koc = 631) and at pH 5.5 (Koc = 2512; non-ionised form) 3.4, respectively.
Executive summary:

The adsorption coefficient (Koc) of N-(4-((4-(3-phenyIureido)phenyI)suIfonyI)phenyI)benzenesuIfonamide on soil and on sewage sludge was determined according to using high performance liquid chromatography (HPLC) as described in the European Commission Regulation (EC) No. 440/2008, method C. 19 and OECD 121 (2001).


The log Koc value of the test substance at pH 7.4 (ionised form) and at pH 5.5 (non-ionised form) was 2.8 and 3.4 (Koc: 631 and 2512), respectively.

Description of key information

The log Koc value of N-(4-((4-(3-phenyIureido)phenyI)suIfonyI)phenyI)benzenesuIfonamide at pH 7.4 (ionised form) was 2.8 (Koc = 631) and at pH 5.5 (Koc = 2512; non-ionised form) 3.4, respectively. The higher Koc value of 2512 is selected for risk assessment as a worst-case.

Key value for chemical safety assessment

Koc at 20 °C:
2 512

Additional information

The test was performed according to the European Commission Regulation (EC) No. 440/2008, method C.19 and OECD 121 (2001).