Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- The MW of recombinant eADF4(C48-CS25C) protein is 142.8 kDa and therefore the likelihood that the substance is capable of crossing biological membranes like the alveoli epithelial cell layer, interstium and the capillary endothelial cell layer very low.
Therefore. there is a low likelihood that an inhaled protein would cross into the systemic circulation to potentially cause pharmacological effects.
In addition,inhalation exposure during manufacturing is unlikely to occur (see attached justification).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
