Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A GLP-compliant short-term fish test on embryo and sac-fry stages was conducted according to OECD 212 with Gobiocypris rarus under semi-static conditions as part of a new chemical substance notification in China. This test is considered as chronic test since it measures the sensitive early life stages from the newly fertilised egg to the end of the sac-fry stage.
Based on nominal concentrations, the 8d-LC10 was 15.4 mg/L, the LC50 was 42.5 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 15.4 mg/L
Additional information
A GLP-compliant short-term fish test on embryo and sac-fry stages was conducted according to OECD 212 with Gobiocypris rarus under semi-static conditions as part of a new chemical substance notification in China. Based on the results of the acute fish test, five treatment groups and a control group were included in the definitive test. The nominal concentrations for the treatment groups were 6.25, 12.5, 25, 50 and 100 mg/L. All treatment groups and blank control group had three replicates each containing 10 embryos and the test duration was 8 days. Since precipitates were formed in the test water, a 24h semi-static test was performed to maintain the concentration of the test substance as much as possible. The hatching success of fertilised eggs and the overal survival of fish larvae in the blank control was 100% and the dissolved oxygen concentration was greater than 70.1% throughout the test. Under the test conditions, based on the nominal concentrations, the 10%, 20% and 50% lethal concentration at the end of the test (LC10, LC20 and LC50) was 15.4, 21.9 and 42.5 mg/L, respectively.
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