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EC number: 242-159-0 | CAS number: 18282-10-5
Nanomaterial dustiness
Administrative data
- Endpoint:
- nanomaterial dustiness
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Pre-Test Trial Equipment (Neat Test Substance)
- Version / remarks:
- Part of OECD Guidelines for Testing of Chemicals, Test No. 403
- Deviations:
- no
- Principles of method if other than guideline:
- 1. Dust Generator: Wright (Modified) or
Fluid Energy Jet-Mill Serial #: J2724E
2. Drive Motor/Dust Delivery Apparatus: Dayton, Model #4Z538A
D.C. speed control with 0-100 potentiometer or
Accurate Dry Material Feeder
3. Air Supply: Air Compressor (Powerex, Model: SES05)
4. Dust Container: Model DF183
5. Cutting Head/Blade: Stainless steel head, Model DF194SS
Stainless steel blade, Model DF191SS
6. Chamber: 6.7 or 28 liter (Nose-Only Inhalation
Chamber, ADG Developments LTD)
7. Airflow Measurements: Mass Flowmeter (Aalborg Model #GFC-17)
8. Grinding Apparatus 1.6-gallon urethane-lined milling jar (Abbethane, Paul O'Abbe)
9. Packing Press Carver Lab Press
Pre-Test Trial Equipment (Diluted Test Substance)
1. Pump Model: Peristaltic pump (Master Flex, Model #7520-35)
2. Tubing for Pump: Size 16 Tygon tubing
3. Air Supply: Air Compressor (Powerex Model: SES05)
4. Atomization: ¼ inch JCO Atomizer (Spraying Systems Co.)
5. Fluid Cap: FC3 (Robert Miller Associates)
6. Air Cap: 70SS (Spraying Systems Co.)
7. Chamber: 28 liter (Nose-Only Inhalation Chamber,
ADG Developments LTD)
8. Airflow Measurements: Mass Flowmeter (Aalborg, Model #GFC-17) - GLP compliance:
- not specified
- Other quality assurance:
- other: The quality management system in place at CEA is certified according to ISOQOO1:2015
- Type of method:
- continuous drop
- Details on methods and data evaluation:
- 1. Dust Generator: Wright (Modified) or
Fluid Energy Jet-Mill Serial #: J2724E
2. Drive Motor/Dust Delivery Apparatus: Dayton, Model #4Z538A
D.C. speed control with 0-100 potentiometer or
Accurate Dry Material Feeder
3. Air Supply: Air Compressor (Powerex, Model: SES05)
4. Dust Container: Model DF183
5. Cutting Head/Blade: Stainless steel head, Model DF194SS
Stainless steel blade, Model DF191SS
6. Chamber: 6.7 or 28 liter (Nose-Only Inhalation
Chamber, ADG Developments LTD)
7. Airflow Measurements: Mass Flowmeter (Aalborg Model #GFC-17)
8. Grinding Apparatus 1.6-gallon urethane-lined milling jar (Abbethane, Paul O'Abbe)
9. Packing Press Carver Lab Press
Pre-Test Trial Equipment (Diluted Test Substance)
1. Pump Model: Peristaltic pump (Master Flex, Model #7520-35)
2. Tubing for Pump: Size 16 Tygon tubing
3. Air Supply: Air Compressor (Powerex Model: SES05)
4. Atomization: ¼ inch JCO Atomizer (Spraying Systems Co.)
5. Fluid Cap: FC3 (Robert Miller Associates)
6. Air Cap: 70SS (Spraying Systems Co.)
7. Chamber: 28 liter (Nose-Only Inhalation Chamber,
ADG Developments LTD)
8. Airflow Measurements: Mass Flowmeter (Aalborg, Model #GFC-17)
Test material
- Reference substance name:
- Tin dioxide
- EC Number:
- 242-159-0
- EC Name:
- Tin dioxide
- Cas Number:
- 18282-10-5
- Molecular formula:
- O2Sn
- IUPAC Name:
- tin(4+) dioxidandiide
- Test material form:
- solid: nanoform
- Details on test material:
- Sample Reference: W0167
Constituent 1
- Specific details on test material used for the study:
- Tin Dioxide use for the study is the same nanomaterial substance on which SET and Particle size distribution tests have been performed.
Reference material / nanomaterial and sample identification number
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- tin(4+) dioxidandiide
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 242-159-0]
- CAS number:
- 18282-10-5
- Identifier:
- CAS number
- Identity:
- 18282-10-5
- Identifier:
- EC name
- Identity:
- Tin Dioxide
- Identifier:
- EC number
- Identity:
- 242-159-0
- Identifier:
- IUPAC name
- Identity:
- Tin dioxide
- Identifier:
- IUPAC name
- Identity:
- tin(4+) dioxidandiide
- Identifier:
- IUPAC name
- Identity:
- tin(4+) ion dioxidandiide
- Identifier:
- IUPAC name
- Identity:
- tin(4+) ion dioxidandiide
- Identifier:
- other: Molecular formula
- Identity:
- O2 Sn
- Identifier:
- other: SMILES notation
- Identity:
- O=[Sn]=O
- Identity:
- Tin Dioxide
- Molecular formula:
- O2Sn
- Molecular weight:
- 150.71
- SMILES notation:
- [Sn](=O)=O
- InChl:
- InChI=1S/2O.Sn
- Identifier:
- CAS number
- Identity:
- 18282-10-5
Results and discussion
Dustiness index
- Key result
- Mean:
- 2.03 mg/kg
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
Trial No. |
Generator/ Mixing Air Pressure (psi) |
Compressed Generator Air (Lpm) |
Compressed Mixing Air (Lpm) |
Total Air Volume (Lpm) |
Pump Setting |
Wet Chamber Conc. (mg/L) |
Calculated Chamber Conc.1(mg/L) |
Particle Size Sampled |
1 |
30/30 |
30.0 |
6.0 |
36.0 |
15.0 |
5.85 |
1.46 |
No |
2 |
30/30 |
30.0 |
6.0 |
36.0 |
30.0 |
7.38 |
1.84 |
Yes |
3 |
30/30 |
30.0 |
6.0 |
36.0 |
45.0 |
6.28 |
1.58 |
No |
4 |
30/30 |
30.0 |
6.0 |
36.0 |
35.0 |
7.28 |
1.82 |
No |
TABLE 2: PRE-TEST EXPOSURE TRIALS
DRY WEIGHT GRAVIMETRIC CHAMBER CONCENTRATION DETERMINATION |
||||||
Trial No. |
Wet Test Substance Collected (mg) |
Total Air Sampled (liters) |
Wet Chamber Conc.1(mg/L) |
Dried Test Substance Collected2(mg) |
Calculated Wet Weight3(mg) |
Calculated Chamber Conc.4(mg/L) |
1 |
23.4 |
4 |
5.85 |
6.7 |
26.5 |
1.66 |
2 |
29.5 |
4 |
7.38 |
8.2 |
32.4 |
2.03 |
3 |
25.1 |
4 |
6.28 |
7.0 |
27.7 |
1.73 |
4 |
29.1 |
4 |
7.28 |
8.2 |
32.4 |
2.03 |
DETERMINATION OF % SOLIDS - CONTROL FILTERS |
|||||||
Filter No. |
Filter Weight (g) |
Wet Filter Weight(g) |
Wet Test Substance Weight (mg) |
Dried Filter Weight (g) |
Dried Test Substance Weight (mg) |
% Solids5 |
|
Trials |
|||||||
1 |
0.1539 |
0.2097 |
55.8 |
0.1681 |
14.2 |
25.4 |
|
2 |
0.1530 |
0.2085 |
55.5 |
0.1670 |
14.0 |
25.2 |
|
3 |
0.1530 |
0.2105 |
57.5 |
0.1673 |
14.3 |
24.9 |
|
4 |
0.1598 |
0.2168 |
57.0 |
0.1744 |
14.6 |
25.6 |
|
Average: |
25.3 |
||||||
The wet chamber concentration was multiplied by the concentration of the test substance (0.25) to arrive at the calculated chamber concentration. This concentration represents the concentration of test substance in the atmosphere. 2Weight of test substance collected after drying overnight in a dessicator. 3Calculated wet weight = (Weight of Dried Test Substance ) x 100 Average % Solids 4Calculated Gravimetric Chamber Concentration = Calculated Wet Weight x Conc. of test substance (0.25) Total Air Sampled 5% Solids = (Dried Weight of Test Substance) x 100 (Wet Weight of Test Substance) |
|
||||||
Applicant's summary and conclusion
- Conclusions:
- the test substance as a powder clogged all dust generator equipment used during preliminary testing (see Table 1). Therefore, the unground test substance was diluted to a 25% w/w dilution in distilled water for all trials conducted. In addition, it was decided that a dry weight gravimetric measurement procedure was to be used (see Section 5.B.6).
The exposure procedures and atomization equipment used were based on the results of pre-test trial number 2 which provided a gravimetric concentration of 2.03 mg/L with a mass median aerodynamic diameter of 2.21 μm. - Executive summary:
The test substance as a powder clogged all dust generator equipment used during preliminary testing (see Table 1). Therefore, the unground test substance was diluted to a 25% w/w dilution in distilled water for all trials conducted. In addition, it was decided that a dry weight gravimetric measurement procedure was to be used (see Section 5.B.6).
The exposure procedures and atomization equipment used were based on the results of pre-test trial number 2 which provided a gravimetric concentration of 2.03 mg/L with a mass median aerodynamic diameter of 2.21 μm.
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