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EC number: 909-044-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There no data on acute toxicity on phosphonic ester residue available.
For acute oral toxicity an overall LD50 value was calculated (LD50=1816 mg/kg bw) based on the available information of the individual components taking into account the requirements of GHS/CLP RegulationNo 1272/2008. For dermal acute toxicity and for acute toxicity via inhalation no studies have to be required because phosphonic ester residue is evaluated to be corrosive.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is no data on acute toxicity on phosphonic ester residue available
Phosphonic ester residue contains monomethyl phosphonate, phosphonic acid, and Dimethylphosphonate, and salt of pyrophosphoric acid and phosphate which were not further specified ORAL EXPOSUREMonomethylphosphonate
Marhold (1986) reported LD50(rat, oral) = 1740 mg/kg bw, details were not given.
Phosphonic acid
Acute oral toxicity of phosphonic acid was examined according to OECD TG 401 with female Wistar rats and yield LD50 = 1720 mg/kg bw (details are not given, ECB 2000).
Dimethylphosphonate
NTP, 1985 reported the oral LD50 of dimethyl phosphonate which was determined by acute oral toxicity study conducted with a method similar to OECD guideline 401 with deviations (no GLP study, environmental conditions not reported; body weights not recorded; fasting period too short). The LD50 of dimethyl phosphonate was calculated to be 3040 mg/kg bw in female Fischer 344 rats (95% confidence limits of 2627-3656 mg/kg) and 3283 mg/kg bw in male rats (95% confidence limits of 2729-3949 mg/kg). Clinical signs of toxicity, which have been observed after oral administration of dimethyl phosphonate, were inactivity, weakness, prostration and shallow breathing in rats.
salt Pyrophosphoric acid and phosphate are not further specified
no data available
OVERALL CONCLUSION ON ACUTE ORAL TOXICITY
According to Regulation (EC) No.1272/2008 GHS-CLP the LD50 can be estimated by the formula given in section 3.1.3.6.2.3. because two components of the product are of unknown acute oral toxicity accounting for > 10% of phosphonic ester residue.
Assuming that the product contains approx 30 % phosphonic acid, and approx 11 % Dimethylphosphonate , approx 49 % monomethyl phosphonate, the overall calculated LD50(oral, rat) value for phosphonic ester residue is 1816 mg/kg bw.
However, according to Regulation (EC) 1907/2006 (REACh) ANNEX VIII section 8.5 (Acute Toxicity) a study does not generally need to be conducted if the substance is classified as corrosive to the skin
INHALATION EXOSURE
There are no data available on -phosphonic ester residue to estimate the inhalation toxicity. However, according to Regulation (EC) 1907/2006 (REACh) ANNEX VIII section 8.5 (Acute Toxicity) The study does not generally need to be conducted if the substance is classified as corrosive to the skin
However, the only available data resulted from Dimethylhydrogenphosphit accounting for 11% within phosphonic ester residue. The LC50 (rabbit, inhalation) is >7100 mg/m³,which does not lead to classification
DERMAL EXPOSURE
There are no data available on -phosphonic ester residue to estimate the dermal toxicity. However, according to Regulation (EC) 1907/2006 (REACh) ANNEX VIII section 8.5 (Acute Toxicity) The study does not generally need to be conducted if the substance is classified as corrosive to the skin.
However, the only available data resulted from Dimethylhydrogenphosphit accounting for 11% within phosphonic ester residue. The LD50 (rabbit, dermal) is 681 mg/kg bw which is not taken into account based on severe methologic deficiencies.
Justification for selection of acute toxicity – oral endpoint
There no data on acute toxicity on phosphonic ester residue available. According to Regulation (EC) 1907/2006 (REACh) ANNEX VII section 8.5 (Acute Toxicity) a study does not generally need to be conducted if the substance is classified as corrosive to the skin.
However; according to Regulation (EC) No.1272/2008 GHS-CLP the LD50 can be estimated by the formula given in section 3.1.3.6.2.3. because two components of the product are of unknown acute oral toxicity accounting for > 10% of phosphonic ester residue.
Assuming that the product contains approx 30 % phosphonic acid (LD50=1720 mg/kg bw ), and approx 11 % Dimethylphosphonate (LD50=3040 mg/kg bw), approx 49 % monomethyl phosphonate (LD50= 1740 mg/kg bw), the overall calculated LD50 (oral, rat) value for phosphonic ester residue is 1816 mg/kg bw.
Justification for selection of acute toxicity – inhalation endpoint
There no data on acute toxicity on phosphonic ester residue available. Phosphonic ester residue is evaluated to be corrosive, based on the study result of a mixture component. Consequently, according to ANNEX VII column 2 no study has to be conducted
Justification for selection of acute toxicity – dermal endpoint
There no data on acute toxicity on phosphonic ester residue available. Phosphonic ester residue is evaluated to be corrosive based on the study result of a mixture component. Consequently, according to ANNEX VII column 2 no study has to be conducted
Justification for classification or non-classification
According to Regulation (EC) 1272/ 2008 Phosphonic ester residue is allocated to category 4, H302 = harmfull if swallowed based on the calculated data of acute oral toxicity.
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