Registration Dossier
Registration Dossier
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EC number: 700-518-3 | CAS number: 38233-76-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50, 48 hours, Daphnia Magna = 59.8 µg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 59.8 µg/L
Additional information
An acute immobilisation assay in Daphnia Magna was conducted (Huntingdon Life Sciences, 2013, Study code VHJ0017) to assess the effect of ETD on aquatic invertebrates. The study was conducted according to EC test method C2 and OECD test guideline 202, and in compliance with GLP. The study was performed in closed vessels with no headspace to avoid loss of the test material due to volatility.
The 48-hour EC50 value for immobilisation in Daphnia Magna was determined to be 59.8 µg/L (95% confidence limits 47.9 - 66.4 µg/L). The no observed effect concentration (NOEC) was 22.8 µg/L.
ECOSAR (EPI Suite ECOSAR, v1), a computer model, was used to estimate the toxicity to Daphnia of ETD. ETD was classified as a Neutral Organic compound, and the partition coefficient was used to calculate the acute and chronic LD50 values. Narcosis was predicted to be the principal mode of action.
The acute LD50 to Daphnia was estimated to be 0.175 mg/L. It was noted that this value was above the measured water solubility for ETD, and so ETD may not be soluble enough to measure the predicted effect.
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