Registration Dossier
Registration Dossier
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EC number: 297-474-6 | CAS number: 93572-43-1 A complex combination of hydrocarbons obtained by refining of crude oil. It consists predominantly of aromatics, naphthenics and paraffinics and produces a finished oil with a viscosity of 120 SUS at 100°F (23cSt at 40°C).
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study summary report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS
- Author:
- American Petroleum Institute
- Year:
- 2 003
- Bibliographic source:
- ROBUST SUMMARY OF INFORMATION ON LUBRICATING OIL BASESTOCKS pag 28
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- other: The test procedure was consistent with that given in OECD Guideline 402 (1987)
Test material
- Reference substance name:
- Distillates (petroleum), light paraffinic
- EC Number:
- 265-051-5
- EC Name:
- Distillates (petroleum), light paraffinic
- Cas Number:
- 64741-50-0
- IUPAC Name:
- 64741-50-0
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 1 day
- Doses:
- 2 g /kg
- No. of animals per sex per dose:
- 4
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
Any other information on results incl. tables
There were no mortalities during the study. With the exception of skin irritation, there were no clinical signs of toxicity except that on day 4 soft stool was observed in 1 male and 3 female animals. Dermal irritation ranged from slight to severe for erythema and edema, from slight to marked for fissuring and slight to moderate for atonia and desquamation. Slight coriaceousness was also observed. Body weight losses were recorded for 2 male and 3 female animals at day 7. One male was less than starting weight on both day 7 and day 14.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
