Registration Dossier
Registration Dossier
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EC number: 233-135-0 | CAS number: 10043-01-3
Toxic effects on livestock and pets
Administrative data
- Endpoint:
- toxic effects on livestock and pets
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: see priciples of method
- Principles of method if other than guideline:
- Type of experience: Livestock - Exposure through Feeding
Method: Two experiments were conducted to evaluate the effect of high levels of inorganic sulfate intake on the growth, feed intake and feaces consistency. 40 pigs with an average age of 5d were individually caged abd reared with an automatic feeding device. Ten pigs per dietary treatment were fed one of four diets containing the following levels of inorganic sodium sulfate (mg/l diet): 0, 1200, 1600, 2000 for exp 1 (18 days study), and 0, 1800, 2000, 22000 for exp. 2 (16 days study). - GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium sulphate
- EC Number:
- 231-820-9
- EC Name:
- Sodium sulphate
- Cas Number:
- 7757-82-6
- IUPAC Name:
- disodium sulfate
- Details on test material:
- - Name of test material :sodium sulphate
CAS number:7757-82-6
EC number:231-820-9
Constituent 1
Test animals
- Species:
- other: pig
- Sex:
- male/female
- Details on test animals and environmental conditions:
- 40 pigs with an average age of 5d were individually caged abd reared with an automatic feeding device. Ten pigs per dietary treatment were fed one of four diets containing the following levels of inorganic sodium sulfate (mg/l diet): 0, 1200, 1600, 2000 for exp 1 (18 days study), and 0, 1800, 2000, 22000 for exp. 2 (16 days study).
Administration / exposure
- Route of exposure:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Ten pigs per dietary treatment were fed one of four diets containing the following levels of inorganic sodium sulfate (mg/l diet): 0, 1200, 1600, 2000 for exp 1 (18 days study), and 0, 1800, 2000, 22000 for exp. 2 (16 days study).
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 16 and 18 days study
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0, 1200, 1600, 2000 for exp 1 (18 days study)
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
0, 1800, 2000, 22000 for exp. 2 (16 days study).
Basis:
nominal in diet
- No. of animals per sex per dose:
- 40 pigs with an average age of 5d male and female
- Control animals:
- yes
Results and discussion
- Clinical signs and mortality:
- no effects
- Body weight and weight gain:
- no effects
- Food consumption and compound intake (if feeding study):
- no effects
- Water consumption and compound intake (if drinking water study):
- no effects
- Haematology:
- yes
- Clinical chemistry:
- yes
- Urinalysis:
- yes
- Gross pathology and organ weights:
- yes
- Histopathology:
- yes
- Details on results:
- The levels of sulfate did not affect (P>0.05) the growth of piglets, or their food intake. 1200 mg/l sulfate had no effect on feaces consistency, while 1800 mg/l sulfate did (non-pathogenic diarrhea). Added sulfate did not affect (P> 0.05) relative kidney weight. The results suggest that the level of added dietary inorganic sulfate at which 50% of piglets develop nonpathogenic diarrhea is between 1600 and 1800 mg/l.
Applicant's summary and conclusion
- Conclusions:
- The results suggest that the level of added dietary inorganic sulfate at which 50% of piglets develop nonpathogenic diarrhea is between 1600 and 1800 mg/l.
- Executive summary:
The levels of sulfate did not affect (P>0.05) the growth of
piglets, or their food intake. 1200 mg/l sulfate had no
effect on feaces consistency, while 1800 mg/l sulfate did
(non-pathogenic diarrhea). Added sulfate did not affect (P>
0.05) relative kidney weight. The results suggest that the
level of added dietary inorganic sulfate at which 50% of
piglets develop nonpathogenic diarrhea is between 1600 and
1800 mg/l.
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