Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 403-530-4 | CAS number: 129423-54-7 PV-ECHTGELB HGR
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted in compliance with GLP standards according to Guideline 84/449/EWG, B.1 and OECD 401 (1987). However, full study report is not available as the data is > 12 year old and summaries have been prepared using data provided by ECHA.
Data source
Reference
- Reference Type:
- other: Body resposible for the test
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 82/449/EWG, B.1, OECD 401 (1987)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Calcium 4-chloro-2-(5-hydroxy-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylazo)-5-methylbenzenesulfonate
- EC Number:
- 403-530-4
- EC Name:
- Calcium 4-chloro-2-(5-hydroxy-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylazo)-5-methylbenzenesulfonate
- Cas Number:
- 129423-54-7
- Molecular formula:
- C17H13CaClN4O7S2
- IUPAC Name:
- calcium 4-chloro-5-methyl-2-{2-[3-methyl-5-oxo-1-(3-sulfonatophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazen-1-yl}benzene-1-sulfonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar Hoe: WISKf (SPF71)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 10% suspension in Sesamol
- No. of animals per sex per dose:
- Male: 5
Female: 5 - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw , number of animals=5 , number of deaths=0
Female: 2000 mg/kg bw , number of animals=5 , number of deaths=0 - Clinical signs:
- other: Signs of toxicity related to dose level: No signs of poisoning occurred during the entire test period. Yellow discoloured faeces were observed from the 1st to 3rd day.
- Gross pathology:
- Effects on organs: No anomalies
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The study was carried out in compliance with GLP according to guideline 84/449/EWG, B.1 and OECD 401. The LD50 is > 2000 mg/kg bw.
- Executive summary:
No systemic toxic effects were described after single oral application of the dose level 2000 mg/kg of the substance to rats. No signs of poisoning occurred during the entire test period. Yellow discoloured faeces were observed from the 1st to 3rd day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
