Registration Dossier
Registration Dossier
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EC number: 211-720-1 | CAS number: 691-37-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
Increase of urea nitrogen was observed at the end of the administration period, and increases of creatinine and chloride were observed at the end of the recovery period in females given 1000 mg/kg/day. Hyaline droplets and eosinophilic bodies in proximal tubular epithelium were observed in males given 200 mg/kg or more. However no effects were observed on reproductive performance of parents or on developmental performance in pups. The NOAELs for systemic toxicity for parents are considered to be 40 mg/kg/day for males, 200 mg/kg/day for females, but for reproductive and developmental toxicity are considered to be 1000 mg/kg/day for parents and pups.
Short description of key information:
The NOAELs for reproductive and developmental toxicity are considered to be 1000 mg/kg/day for parents and pups (OECD 422).
Effects on developmental toxicity
Description of key information
The NOAELs for reproductive and developmental toxicity are considered to be 1000 mg/kg/day for parents and pups (OECD 422).
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
Increase of urea nitrogen was observed at the end of the administration period, and increases of creatinine and chloride were observed at the end of the recovery period in females given 1000 mg/kg/day. Hyaline droplets and eosinophilic bodies in proximal tubular epithelium were observed in males given 200 mg/kg or more. However no effects were observed on reproductive performance of parents or on developmental performance in pups. The NOAELs for systemic toxicity for parents are considered to be 40 mg/kg/day for males, 200 mg/kg/day for females, but for reproductive and developmental toxicity are considered to be 1000 mg/kg/day for parents and pups.
Justification for classification or non-classification
The NOAELs for reproductive and developmental toxicity are considered to be 1000 mg/kg/day for parents and pups, therefore according to Regulation (EC)1272/2008 the substance is not considered to be classified.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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