Propanoic acid, 2-hydroxy-, propyl ester, (2S)-

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2010-07-02 to 2010-08-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

adopted 27th July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

adopted 31st May 2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

- Name of test material used in the report: Purasolv NPL
- CAS no.: 53651-69-7
- Batch no.: 0908000392
- Appearance: clear colourless liquid
- Purity: 99.3% w/w
- Storage: at room temperature in the dark under nitrogen
- Expiry date: 2010-08-13

Key result

Melting / freezing pt.:

-31 °C

During the first as well as the second experiment, essentially the same results were obtained. For the experiment an internally scratched sample pan was used in order to facilitate crystallisation. Cooling showed a crystallisation peak between -70 and -60 °C. Melting of the test substance was observed between -50 and -10 °C with an extrapolated onset of -31.38 °C (first experiment) and -31.15 °C (second experiment). After the experiment, the test substance was visually unchanged.

Conclusions:

The melting point was determined by an experimental study conducted according to OECD TG 102. The melting point of Propyl (S)-lactate was determined to be -31 °C at atmospheric pressure.

Executive summary:

The melting temperature of the test substance were determined using differential scanning calorimetry (DSC) in an experimental study conducted according to OECD TG 102. This technique records the difference in heat flow to two crucibles, one filled with test substance and the other filled with an inert reference material, while these crucibles are subjected to a controlled temperature programme. When the test substance undergoes a transition, such as melting or evaporation, it is indicated by a deviation from the base line of the heat-flow record. Because melting and evaporation are processes in which heat is consumed, for these processes the deviation from the base line is in the endothermic direction. The melting temperature of the test substance is evaluated from the DSC curve as the extrapolated onset temperature of the endothermic melting peak. The melting point of Propyl (S)-lactate was determined to be -31 °C at atmospheric pressure.

Description of key information

The melting point was determined by an experimental study conducted according to OECD TG 102. The melting point of Propyl (S)-lactate was determined to be -31 °C at atmospheric pressure.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

-31 °C